Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/50872

Título:

PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes

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Autor:

Autier, Brice
Verger, Alexis
Plaisse, Charleen
Manuel, Christelle
Chollet-Krugler, Marylene
Preza Pérez, Matías Facundo
Lundström-Stadelmann, Britta
Amela-Cortes, Marian
Aninat, Caroline
Samson, Michel
Brandhonneur, Nolwenn
Dion, Sarah

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Artículo

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Palabras clave:

Poly(lactic co-glycolic acid)
Drug delivery system
Alveolar echinococcosis
EmPGI
Drug therapy

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Año de publicación:

2024

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Resumen:

Alveolar echinococcosis (AE) is a severe disease caused by the infection with the larval stage of Echinococcus multilocularis, the metacestode. As there is no actual curative drug therapy, recommendations to manage AE patients are based on radical surgery and prophylactic administration of albendazole or mebendazole during 2 years to prevent relapses. There is an urgent need for new therapeutic strategies for the management of AE, as the drugs in use are only parasitostatic, and can induce toxicity. This study aimed at developing a drug delivery system for mefloquine, an antiparasitic compound which is highly active against E. multilocularis in vitro and in experimentally infected mice. We formulated mefloquine-loaded PLGA-PEG-COOH (poly-(lactic-co-glycolic acid) nanoparticles that exhibit stable physical properties and mefloquine content. These nanoparticles crossed the outer acellular laminated layer of metacestodes in vitro and delivered their content to the inner germinal layer within less than 5 min. The in vitro anti-echinococcal activity of mefloquine was not altered during the formulation process. However, toxicity against hepatocytes was not reduced when compared to free mefloquine. Altogether, this study shows that mefloquine-loaded PLGA-PEG-COOH nanoparticles are promising candidates for drug delivery during AE treatment. However, strategies for direct parasite-specific targeting of these particles should be develop.

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Elsevier

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Experimental Parasitology, 2024, 265: 108811.

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Citación:

Autier, B, Verger, A, Plaisse, C [y otros autores]. "PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes". Experimental Parasitology. [en línea] 2024, 265: 108811. 10 h. DOI: 10.1016/j.exppara.2024.108811

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1090-2449

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones académicas y científicas
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