Título:
Allogeneic stem cell transplantation for bone regeneration of a nonunion defect in a canine
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Autor:
Yaneselli, Kevin
Filomeno, Andrea
Semiglia, Gabriel
Arce, Carolina
Rial, Analía
Muñoz, Natalia
Moreno, María
Erickson, Kent
Maisonnave, Jacqueline
Filomeno, Andrea
Semiglia, Gabriel
Arce, Carolina
Rial, Analía
Muñoz, Natalia
Moreno, María
Erickson, Kent
Maisonnave, Jacqueline
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Artículo
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Palabras clave:
allogeneic
AT-MSCs
treatment
nonunion
canine
AT-MSCs
treatment
nonunion
canine
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Año de publicación:
2013
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Resumen:
Nonunion bone defects occur frequently with local pain, functional limitations, muscular atrophy, and fistulas due to osteomyelitis. The application of mesenchymal stem cells (MSCs) could improve regeneration of bone following bone defects. The objective of the present study was to evaluate the treatment of a nonunion defect due to chronic osteomyelitis in a greyhound female dog with allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs). The implanted cells were adherent to plastic, were of fibroblast type, and expressed the canine stem cell markers CD90low, CD44high, and CD45-. Cell therapy consisted of five percutaneous weekly injections of 2 × 106 allogeneic AT-MSCs into the bone defect (total of 10 × 106 AT-MSCs). The patient was evaluated clinically and radiologically for up to 1 year. The results were clinical improvement, a light lameness score of 1 at week 16, return to use of its forearm, no pain, and increased muscular mass. No signs of osteomyelitis were observed radiologically and clinically there were no fistulas. There was no evidence of local or systemic adverse reactions caused by the alloimplants. The clinical relevance of the cell therapy contributing to repair of bone defects in small animals is a very promising future alternative. These results may have an important impact in new regenerative treatments for animal and human orthopedics.
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Vet. med. 4, 2013
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YANESELLI, K., FILOMENO, A., SEMIGLIA, G., y otros. Allogeneic stem cell transplantation for bone regeneration of a nonunion defect in a canine. Vet. med [en línea] 2013, 4. DOI: 10.2147/VMRR.S50218
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Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Allogeneic stem cell transplantation for bone.pdf | Artículo original | 1.04 MB | Adobe PDF |