| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Gambino, Dinorah | - |
| dc.contributor.author | Autor | Del Mármol, Carolina | - |
| dc.contributor.author | Autor | Scalese, Gonzalo | - |
| dc.contributor.author | Autor | Soba, Mariano | - |
| dc.contributor.author | Autor | Moreira, Rodrigo | - |
| dc.contributor.author | Autor | Machado, Ignacio | - |
| dc.contributor.author | Autor | Pérez Díaz, Leticia | - |
| dc.contributor.author | Autor | Lima, Analía | - |
| dc.contributor.filiacion | Filiación | Gambino Dinorah | - |
| dc.contributor.filiacion | Filiación | Del Mármol Carolina | - |
| dc.contributor.filiacion | Filiación | Scalese Gonzalo | - |
| dc.contributor.filiacion | Filiación | Soba Mariano | - |
| dc.contributor.filiacion | Filiación | Moreira Rodrigo | - |
| dc.contributor.filiacion | Filiación | Machado Ignacio | - |
| dc.contributor.filiacion | Filiación | Pérez Díaz Leticia | - |
| dc.contributor.filiacion | Filiación | Lima Analía | - |
| dc.date.accessioned | Fecha ingreso | 2024-08-08T16:46:34Z | - |
| dc.date.available | Fecha disponible | 2024-08-08T16:46:34Z | - |
| dc.date.issued | Año de publicación | 2024 | - |
| dc.description.abstract | Resumen | Chagas disease (American trypanosomiasis), caused by the protozoan parasite Trypanosoma cruzi, is considered neglected by the World Health Organization. The absence of effective chemotherapy underscores the urgent requirement for the development of novel, potent, and non-toxic drugs. Exploring organometallic compounds has emerged as a promising strategy in the pursuit of improved and safer chemotherapy to tackle this illness. Hybridization of an organometallic center with bioactive organic ligands frequently yields antiparasitic compounds with improved biological properties compared to free ligands and efficacy against multiple parasite targets. Our recent research focuses on the development of multifunctional Re(I) tricarbonyls and their Mn(I) counterparts, namely fac-[M (CO) (NN)(CTZ)](PF ). These compounds integrate two distinct ligands, both with demonstrated activity against T. cruzi: a bidentate 1,10-phenanthroline derivative (NN) and the monodentate Clotrimazole (CTZ). The compounds were synthesized via a stepwise procedure and were thoroughly characterized. Synthetic procedure, solution stability, lipophilicity, and biological properties of both families of metal(I) tricarbonyls were compared. The impact of the compounds on the molecular targets of the free ligands, specifically DNA and CYP51 lanosterol 14-α-demethylase, was investigated. Aiming to provide insights into the compounds' effect on metabolic pathways within the parasite, metallomics and proteomics studies on T. cruzi were conducted for the hit compounds of both series. The whole set of results will be scrutinized to uncover the potential of Mn(I) and Re(I) tricarbonyl compounds in advancing the development of drugs targeting the parasite. | es |
| dc.format.extent | Extensión | 1 p. | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Gambino, D, Del Mármol, C, Scalese, G, Soba, M, Moreira, R, Machado, I, Pérez Díaz, L y Lima, A. Comparing multifunctional Mn(I) and Re(I) tricarbonyls as potential agents against Chagas disease. 45th International Conference on Coordination Chemistry. Colorado, 28 de julio - 03 de agosto, 2024. 1 p. | es |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/45237 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | ICCC | es |
| dc.relation.ispartof | EN | 45th International Conference on Coordination Chemistry, Colorado, 28 de julio - 03 de agosto, 2024 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
| dc.subject | Palabras clave | ENFERMEDAD DE CHAGAS | es |
| dc.subject | Palabras clave | TRYPANOSOMA CRUZI | es |
| dc.title | Título | Comparing multifunctional Mn(I) and Re(I) tricarbonyls as potential agents against Chagas disease | es |
| dc.type | Tipo de documento | Póster | es |
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| Ficheros | Descripción | Tamaño | Formato | ||
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| Oxford AbstractGambinoICCC45.pdf | — | 108.83 KB | Adobe PDF |