Título:
Neuron’s little helper: the role of primary cilia in neurogenesis
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Autor:
Lepanto, Paola
Badano, José L.
Zolessi, Flavio R.
Badano, José L.
Zolessi, Flavio R.
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Hedgehog
Neuroepithelium
Neurogenesis
Neuronal differentiation
Neuronal migration
Primary cilia
Neuroepithelium
Neurogenesis
Neuronal differentiation
Neuronal migration
Primary cilia
Descriptores:
Año de publicación:
2016
Contenido:
Resumen:
The generation of new neurons involves a great variety of cell-extrinsic and cell-intrinsic signals. The primary cilium, long regarded as an “evolutionary vestige,” has emerged as an essential signaling hub in many cells, including neural progenitors and differentiating neurons. Most progenitors harbor an apically-localized primary cilium, which is assembled and disassembled following the cell cycle, while the presence, position and length of this organelle appears to be even more variable in differentiating neurons. One of the main extracellular cues acting through the cilium is Sonic Hedgehog, which modulates spatial patterning, the progression of the cell cycle and the timing of neurogenesis. Other extracellular signals appear to bind to cilia-localized receptors and affect processes such as dendritogenesis. All the observed dynamics, as well as the many signaling pathways depending on cilia, indicate this organelle as an important structure involved in neurogenesis.
Descripción:
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Editorial:
Taylor
Francis
Francis
EN:
Neurogenesis, 2016, 3 (1), e1253363
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Citación:
Lepanto, P., Badano, J.L., Zolessi, F.L. "Neuron's little helpers: the role of primary cilia in neurogenesis". Neurogenesis, 2016, 3 (1), e1253363. doi: 10.1080/23262133.2016.1253363
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ISSN:
0120-5552
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Licencia:
Licencia Creative Commons Atribución – No Comercial -- Compartir igual (CC -BY-NC-SA 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 1010802326213320161253363.pdf | — | 1.43 MB | Adobe PDF |