Título:
Re-appraising the evidence for the source, regulation and function of p53-family isoforms
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Autor:
López Ferreira, Luis Ignacio
Larghero Valdivia, Irene
Vojtesek, Borivoj
Fahraeus, Robin
Coates, Philip J.
Larghero Valdivia, Irene
Vojtesek, Borivoj
Fahraeus, Robin
Coates, Philip J.
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Tipo de documento:
Artículo
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Palabras clave:
Proteins
p53-family
isoforms
p53-family
isoforms
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Año de publicación:
2024
Contenido:
Resumen:
The p53 family of proteins evolved from a common ancestor into three separate genes encoding proteins that act as transcription factors with distinct cellular roles. Isoforms of each member that lack specific regions or domains are suggested to result from alternative transcription start sites, alternative splicing or alternative translation initiation, and have the potential to exponentially increase the functional repertoire of each gene. However, evidence supporting the presence of individual protein variants at functional levels is often limited and is inferred by mRNA detection using highly sensitive amplification techniques. We provide a critical appraisal of the current evidence for the origins, expression, functions and regulation of p53-family isoforms. We conclude that despite the wealth of publications, several putative isoforms remain poorly established. Future research with improved technical approaches and the generation of isoform-specific protein detection reagents is required to establish the physiological relevance of p53-family isoforms in health and disease. In addition, our analyses suggest that p53-family variants evolved partly through convergent rather than divergent evolution from the ancestral gene.
Descripción:
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Editorial:
Oxford University Press
EN:
Nucleic Acids Research, 2024: 1-18
Financiadores:
ANII: FCE_3_2020_1_161877
ANII: FCE_1_2023_1_175762
ANII: MOV_CA_2023_1_176782
ANII: FCE_1_2023_1_175762
ANII: MOV_CA_2023_1_176782
Citación:
López Ferreira, L, Larghero Valdivia, I, Vojtesek, B, [y otros]. "Re-appraising the evidence for the source, regulation and function of p53-family isoforms". Nucleic Acids Research. [en línea] 2024: 1-18. DOI: 10.1093/nar/gkae855
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1362-4962
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1093.nar.gkae855.pdf | — | 2.11 MB | Adobe PDF |