Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/56081

Título:

The complement system in neurodegenerative and inflammatory diseases of the central nervous system

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Autor:

Negro-Demontel, Luciana
Maleki, Adam F.
Reich, Daniel S.
Kemper, Claudia

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Tipo de documento:

Artículo

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Palabras clave:

Brain
Central nervous system
Complement
Complosome
Development

Descriptores:

ENFERMEDADES NEURODEGENERATIVAS
ENCÉFALO
SISTEMA NERVIOSO CENTRAL
ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL
ENFERMEDAD DE PARKINSON
ENFERMEDAD DE ALZHEIMER
ESCLEROSIS MÚLTIPLE
FACTORES DE RIESGO
ANCIANO
HUMANOS

Año de publicación:

2024

Contenido:

Resumen:

Neurodegenerative and neuroinflammatory diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, affect millions of people globally. As aging is a major risk factor for neurodegenerative diseases, the continuous increase in the elderly population across Western societies is also associated with a rising prevalence of these debilitating conditions. The complement system, a crucial component of the innate immune response, has gained increasing attention for its multifaceted involvement in the normal development of the central nervous system (CNS) and the brain but also as a pathogenic driver in several neuroinflammatory disease states. Although complement is generally understood as a liver-derived and blood or interstitial fluid operative system protecting against bloodborne pathogens or threats, recent research, particularly on the role of complement in the healthy and diseased CNS, has demonstrated the importance of locally produced and activated complement components. Here, we provide a succinct overview over the known beneficial and pathological roles of complement in the CNS with focus on local sources of complement, including a discussion on the potential importance of the recently discovered intracellularly active complement system for CNS biology and on infection-triggered neurodegeneration.

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Frontiers Research Foundation

EN:

Frontiers in Neurology. 2024;15

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Citación:

Negro-Demontel L, Maleki A, Reich D y otros. The complement system in neurodegenerative and inflammatory diseases of the central nervous system. Frontiers in Neurology [en línea]. 2024;15. 17 p.

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones Académicas y Científicas
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