Título:
Epidemiology Update of Hepatitis E Virus (HEV) in Uruguay: Subtyping, Environmental Surveillance and Zoonotic Transmission
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Autor:
Cancela, Florencia
Icasuriaga, Romina
Cuevas, Santiago
Hergatacorzian, Valentina
Olivera, Mauricio
Panzera, Yanina
Pérez, Ruben
López, Julieta
Borzacconi, Liliana
González, Elizabeth
Montaldo, Natalia
Gaitán, Melissa
López-Verges, Sandra
Bortagaray, Viviana
Victoria, Matías
Colina, Rodney
Arbiza, Juan
Berois, Mabel
Mirazo, Santiago
Icasuriaga, Romina
Cuevas, Santiago
Hergatacorzian, Valentina
Olivera, Mauricio
Panzera, Yanina
Pérez, Ruben
López, Julieta
Borzacconi, Liliana
González, Elizabeth
Montaldo, Natalia
Gaitán, Melissa
López-Verges, Sandra
Bortagaray, Viviana
Victoria, Matías
Colina, Rodney
Arbiza, Juan
Berois, Mabel
Mirazo, Santiago
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Tipo de documento:
Artículo
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Palabras clave:
Hepatitis E virus
Uruguay
Molecular epidemiology
Subtype 3o
Wastewater
Uruguay
Molecular epidemiology
Subtype 3o
Wastewater
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Año de publicación:
2023
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Resumen:
Hepatitis E Virus (HEV) infection is an emergent zoonotic disease of increasing concern in developed regions. HEV genotype 3 (HEV-3) is mainly transmitted through consumption of contaminated food in high-income countries and is classified into at least 13 subtypes (3a–3n), based on p-distance values from complete genomes. In Latin America, HEV epidemiology studies are very scant. Our group has previously detected HEV3 in clinical cases, swine, wild boars, captive white-collared peccaries, and spotted deer from Uruguay. Herein, we aimed to provide novel insights and an updated overview of the molecular epidemiology of zoonotic HEV in Uruguay, including data from wastewater-based surveillance studies. A thorough analysis of HEV whole genomes and partial ORF2 sequences from Uruguayan human and domestic pig strains showed that they formed a separate monophyletic cluster with high nucleotide identity and exhibited p-distance values over the established cut-off (0.093) compared with reference subtypes’ sequences. Furthermore, we found an overall prevalence of 10.87% (10/92) in wastewater, where two samples revealed a close relationship with humans, and animal reservoirs/hosts isolates from Uruguay. In conclusion, a single, new HEV-3 subtype currently circulates in different epidemiological settings in Uruguay, and we propose its designation as 3o along with its reference sequence.
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EN:
Viruses. 2023, 15
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Citación:
CANCELA, F., ICASURIAGA, R., CUEVAS, S., y otros. Epidemiology Update of Hepatitis E Virus (HEV) in Uruguay: Subtyping, Environmental Surveillance and Zoonotic Transmission. Viruses [en línea] 15, 2023. DOI: 10.3390/v15102006.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Epidemiology Update of Hepatitis E Virus (HEV) in Uruguay.pdf | Artículo original | 1.17 MB | Adobe PDF |