Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/53294

Título:

Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation

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Autor:

Macklin, Michael
Thompson, Chelsea
Kawano-Dourado, Leticia
Bauer Ventura, Iazsmin
Weschenfelder, Camila
Trostchansky, Andrés
Marcadenti, Aline
Tighe, Robert M.

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Tipo de documento:

Artículo

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Palabras clave:

Obesity
Adiposity
Interstitial lung disease
Autoimmunity
Fibrosis
Inflammation

Descriptores:

OBESIDAD
ADIPOSIDAD
ENFERMEDADES PULMONARES INTERSTICIALES
AUTOINMUNIDAD
INFLAMACIÓN
TEJIDO ADIPOSO

Año de publicación:

2023

Contenido:

Resumen:

Adipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detrimental. These detrimental adipose tissue functions can alter normal hormonal signaling and promote local and systemic inflammation with wide-ranging consequences. Although the mechanisms by which adipose tissue triggers metabolic dysfunction and local inflammation have been well described, little is known about the relationship between adiposity and the pathogenesis of chronic lung conditions, such as interstitial lung disease (ILD). In this review, we detail the conditions and mechanisms by which adipose tissue becomes dysfunctional and relate this dysfunction to inflammatory changes observed in various forms of ILD. Finally, we review the existing basic and clinical science literature linking adiposity to ILD, highlighting the need for additional research on the mechanisms of adipocyte-mediated inflammation in ILD and its clinical implications.

Descripción:

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MDPI

EN:

Cells. 2023;12(18)

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Citación:

Macklin M, Thompson C, Kawano-Dourado L y otros. Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation. Cells [en línea]. 2023;12(18). 16 p.

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2073-4409

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones Académicas y Científicas
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