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Título:

Current Status of Regulatory Non-Coding RNAs Research in the Tritryp

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Autor:

Fort, Rafael Sebastián
Chaves, Santiago
Trinidad Barnech, Juan M.
Oliveira-Rizzo, Carolina
Smircich, Pablo
Sotelo Silveira, José Roberto
Duhagon, María Ana

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Artículo

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Palabras clave:

Trypanosoma
Leishmania
ncRNA
Non-coding RNA
siRNA
snRNA
snoRNA
tRNA
Tritryp
Trypanosomatids

Descriptores:

TRYPANOSOMA
LEISHMANIASIS
ARN LARGO NO CODIFICANTE
ARN
ARN PROTOZOARIO

Año de publicación:

2022

Contenido:

Resumen:

Trypanosomatids are protozoan parasites that cause devastating vector-borne human diseases. Gene expression regulation of these organisms depends on post-transcriptional control in responding to diverse environments while going through multiple developmental stages of their complex life cycles. In this scenario, non-coding RNAs (ncRNAs) are excellent candidates for a very efficient, quick, and economic strategy to regulate gene expression. The advent of high throughput RNA sequencing technologies show the presence and deregulation of small RNA fragments derived from canonical ncRNAs. This review seeks to depict the ncRNA landscape in trypanosomatids, focusing on the small RNA fragments derived from functional RNA molecules observed in RNA sequencing studies. Small RNA fragments derived from canonical ncRNAs (tsRNAs, snsRNAs, sdRNAs, and sdrRNAs) were identified in trypanosomatids. Some of these RNAs display changes in their levels associated with different environments and developmental stages, demanding further studies to determine their functional characterization and potential roles. Nevertheless, a comprehensive and detailed ncRNA annotation for most trypanosomatid genomes is still needed, allowing better and more extensive comparative and functional studies.

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MDPI

EN:

Non-coding RNA. 2022;8(4)

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Citación:

Fort R, Chaves S, Trinidad Barnech J y otros. Current Status of Regulatory Non-Coding RNAs Research in the Tritryp. Non-coding RNA [en línea]. 2022;8(4). 22 p.

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Licencia Creative Commons Atribución (CC - By 4.0)

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