Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54649
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dc.contributor.author Autor Ronco, Álvaro Luis-
dc.contributor.author Autor Martínez-López, Wilner-
dc.contributor.author Autor Calderón, Juan M.-
dc.contributor.author Autor Storz, Maximilian Andreas-
dc.contributor.filiacion Filiación Ronco Álvaro Luis, Centro Hospitalario Pereira Rossell (Uruguay). Unidad de Oncología y Radioterapia-
dc.contributor.filiacion Filiación Martínez-López Wilner, Universidad de la República (Uruguay). Facultad de Medicina. Unidad Académica de Radioprotección-
dc.contributor.filiacion Filiación Calderón Juan M., Universidad de Montevideo (Uruguay). Centro de Ciencias Biomédicas-
dc.contributor.filiacion Filiación Storz Maximilian Andreas, University of Freiburg (Alemania). Faculty of Medicine. Department of Internal Medicine II-
dc.date.accessioned Fecha ingreso 2026-04-28T17:21:50Z-
dc.date.available Fecha disponible 2026-04-28T17:21:50Z-
dc.date.issued Año de publicación 2022-
dc.description.abstract Resumen Background: A high dietary acid load (DAL) can produce metabolic acidosis, which is linked to cancer development through mechanisms of inflammation and cell transformation. There is limited epidemiological evidence linking DAL and cancer risk; however, none of the published studies focused on DAL and esophageal cancer (EC) risk in particular. Therefore, we sought to explore this association in the present study. Methods: A case-control study was performed in 1295 male patients (185 squamous cell EC cases and 1110 age-frequency and urban/rural residence matched controls) through a multitopic inquiry, including a food frequency questionnaire. Food-derived nutrients were calculated from available databases. The DAL was calculated based on two validated measures: Potential renal acid load (PRAL) score and net endogenous acid production (NEAP) score. Odds ratios (OR) and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression, adjusting for confounders. Results: We found direct, significant associations between dietary acid load and EC risk: (OR = 2.28, 95% CI: 1.44-3.61, ptrend <0.0001) and (OR = 2.17, 95% CI: 1.38-3.41, ptrend <0.0001) for highest PRAL and NEAP tertiles, respectively. Our data raise the possibility that a high DAL may contribute to EC development. Both acid load scores were directly associated with animal-based foods (mainly meat) and inversely associated with the intake of plant-based foods. Conclusion: To the best of our knowledge, this is the first epidemiological case-control study analyzing associations of DAL and squamous cell EC risk. Further research is warranted to confirm our findings.es
dc.format.extent Extensión 8 p.es
dc.format.mimetype Formato application/pdfes
dc.identifier.citation Citación Ronco Á, Martínez-López W, Calderón J y otros. Dietary acid load and esophageal cancer risk: A case-control study. Thoracic Cancer [en línea]. 2022;13(19):2759-2766es
dc.identifier.doi DOI 10.1111/1759-7714.14612-
dc.identifier.eissn e-ISSN 1759-7714-
dc.identifier.uri URI https://hdl.handle.net/20.500.12008/54649-
dc.language.iso Idioma enes
dc.publisher Editorial Wileyes
dc.relation.ispartof EN Thoracic Cancer. 2022;13(19):2759-2766es
dc.rights Derechos Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)es
dc.rights.licence Licencia Licencia Creative Commons Atribución (CC - By 4.0)es
dc.subject Palabras clave NEAPes
dc.subject Palabras clave PRALes
dc.subject Palabras clave Canceres
dc.subject Palabras clave Dietary acid loades
dc.subject Palabras clave Epidemiologyes
dc.subject Palabras clave Esophaguses
dc.subject.other Descriptores ÁCIDOSes
dc.subject.other Descriptores METABOLISMOes
dc.subject.other Descriptores DESEQUILIBRIO ÁCIDO-BASEes
dc.subject.other Descriptores NEOPLASIAS ESOFÁGICASes
dc.subject.other Descriptores ACIDOSISes
dc.subject.other Descriptores EPIDEMIOLOGÍAes
dc.subject.other Descriptores EFECTOS ADVERSOS A LARGO PLAZOes
dc.subject.other Descriptores ANIMALESes
dc.subject.other Descriptores ESTUDIOS DE CASOS Y CONTROLESes
dc.subject.other Descriptores NUTRICIÓN, ALIMENTACIÓN Y DIETAes
dc.subject.other Descriptores HUMANOSes
dc.subject.other Descriptores FACTORES DE RIESGOes
dc.title Título Dietary acid load and esophageal cancer risk: A case-control studyes
dc.type Tipo de documento Artículoes

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