Título:
Immunology of a unique biological structure: the Echinococcus laminated layer
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Autor:
Díaz, Álvaro
Barrios, Anabella A.
Grezzi, Leticia
Mouhape, Camila
Jenkins, Stephen J.
Allen, Judith E.
Casaravilla, Cecilia
Barrios, Anabella A.
Grezzi, Leticia
Mouhape, Camila
Jenkins, Stephen J.
Allen, Judith E.
Casaravilla, Cecilia
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Artículo
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MUCINAS
ECHINOCOCCUS
MACROFAGO
CELULA DENDRITICA
ECHINOCOCCUS
MACROFAGO
CELULA DENDRITICA
Año de publicación:
2023
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Resumen:
The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species. The resulting diseases, collectively termed echinococcoses, include major neglected tropical diseases of humans and livestock. Echinococcus larvae are outwardly protected by the laminated layer (LL), an acellular structure that is unique to this genus. The LL is based on a fibrillar meshwork made up of mucins, which are decorated by galactose-rich O-glycans. In addition, in the species cluster termed E. granulosus sensu lato, the LL features nano-deposits of the calcium salt of myo-inositol hexakisphosphate (Insp6).
The main purpose of our article is to update the immunobiology of the LL. Major recent advances in this area are (i) the demonstration of LL “debris” at the infection site and draining lymph nodes, (ii) the characterization of the decoy activity of calcium Insp6 with respect to complement, (iii) the evidence that the LL mucin carbohydrates interact specifically with a lectin receptor expressed in Kupffer cells (Clec4F), and (iv) the characterization of what appear to be receptor-independent effects of LL particles on dendritic cells and macrophages. Much information is missing on the immunology of this intriguing structure: we discuss gaps in knowledge and propose possible avenues for research.
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Oxford University Press
EN:
Protein Cell v.14, n°2, 2023. -- pp. 87-104
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Citación:
Díaz, Á, Barrios, A, Grezzi, L, y otros. "Immunology of a unique biological structure: the Echinococcus laminated layer". Protein Cell. [en línea] 2023, vol. 14, n°2, pp. 87-104. DOI: https://doi.org/10.1093/procel/pwac023
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| AA Díaz, A. et al v.14 Protein _ Cell 2023.pdf | — | 2.25 MB | Adobe PDF |