Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/53596

Título:

Multifocal epithelial hyperplasia: clinical features, diagnosis and management challenges.

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Autor:

Ramos-Gregorio, César Omar
Tremillo-Maldonado, Omar
Silveira, Felipe Martins
Schuch, Lauren Frenzel
Pereira-Prado, Vanesa
Sicco, Estefanía
Soto-Najera, Ana Cristina
Gómez Palacio Gastelum, Marcelo
Isiordia-Espinoza, Mario Alberto
Muñoz Ibarra, Juan José
Toral-Rizo, Victor Hugo
Bologna-Molina, Ronell

Tutor:

Tipo de documento:

Artículo

Editor:

Palabras clave:

Diagnóstico molecular
Lesiones orales

Descriptores:

HIPERPLASIA EPITELIAL FOCAL
VIRUS DEL PAPILOMA HUMANO
PUEBLOS INDIGENAS
EQUIDAD EN SALUD
EPIDEMIOLOGIA

Año de publicación:

2025

Contenido:

Resumen:

Multifocal epithelial hyperplasia (MEH), also known as Heck’s disease, is a rare and benign condition of the oral mucosa that is strongly associated with low-risk human papillomavirus (HPV) genotypes 13 and 32. This narrative review synthesizes recent findings regarding the epidemiology, viral mechanisms, clinical and histopathological features, diagnostic strategies-including molecular and immunohistochemical methods-and therapeutic approaches to MEH. This disease predominantly affects children and adolescents from Indigenous American countries, although cases have been increasingly reported in nonendemic regions. MEH manifests clinically as multiple, asymptomatic papules or nodules, typically exhibiting a characteristic cobblestone-like appearance. Histologically, it presents with epithelial hyperplasia, koilocytosis, and altered cytokeratin expression. Molecular techniques such as polymerase chain reaction and in situ hybridization are pivotal for accurate viral genotyping, while immunohistochemical markers such as CK4/13, Ki-67, and the absence of p16 can be useful adjuncts in differential diagnosis. Despite its self-limiting nature in most cases, treatment may be warranted in symptomatic or immunocompromised patients. This review highlights the need to improve diagnostic access, develop targeted vaccines, and implement public health strategies in vulnerable communities. It also highlights existing gaps in knowledge, particularly regarding host-virus interactions and the absence of standardized treatment protocols.

Descripción:

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Editorial:

Baishideng

EN:

World Journal of Experimental Medicine, 2025, 15(4): 114368.

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Citación:

Ramos-Gregorio, C, Tremillo-Maldonado, O, Silveira, F, [y otros autores]. "Multifocal epithelial hyperplasia: clinical features, diagnosis and management challenges". World Journal of Experimental Medicine. [en línea] 2025, 15(4): 114368.

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ISSN:

2220-315x

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Licencia:

Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)

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Publicaciones académicas y científicas 2020-
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