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Título:

Comparative genomics of the major parasitic worms

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Autor:

Coghlan, A.
Cotton, J.A.
Holroyd, N.
Reid, A.J.
Ribeiro, D.M.
Stanley, Eleanor
Beasley, H.
Bennett, H.M.
Doyle, S.R.
Gordon, D.
Harsha, B.
Huckvale, T.
Lomax, J.
Rinaldi, Gabriel
Shafie, M.
Tracey, A.
Berriman, Matthew
Tyagi, R.
Rosa, B.A.
Tsai, I.J.
Laetsch, D.R.
Beech, R.N.
Day, T.A.
Hallsworth-Pepin, K.
Huei-Mien, K.
Tzu-Hao, K.
Lee, T.J.
Martin, J.
Maizels, R.M.
Mutowo, P.
Ozersky, P.
Parkinson, J.
Rawlings, N.D.
Swapna, L.S.
Taylor, D.W.
Wheeler, N.J.
Zamanian, M.
Xu, Z.
Allan, F.
Allen, Judith E.
Asano, K.
Babayan, S.A.
Bah, G.
Bisset, S.A.
Castillo Presa, Estela Beatriz
Cook, J.
Cooper, P.J.
Cruz-Bustos, T.
Cuéllar, C.
Devaney, E.
Eberhard, M.L.
Emery, A.
Eom, K.S.
Gilleard, J.S.
Harcus, Y.
Hawdon, J.M.
Hill, D.E.
Hodgkinson, J.
Horák, P.
Howe, K.L.
Kalbe, M.
Kaur, G.
Kikuchi, T.
Koutsovoulos, G.
Kumar, S.
Leach, A.R.
Makepeace, B.
Matthews, J.B.
Muro, A.
O’Boyle, N.M.
Olson, P.D.
Partono, F.
Pfarr, K.
Foronda, P.
Rollinson, D.
Gomez Samblas, M.
Sato, H.
Schnyder, M.
Scholz, T.
Tanya, V.N.
Toledo, R.
Urban, J.F.
Lian-Cheng, W.
Zarlenga, D.
Blaxter, M.L.
Mitreva, M.

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Artículo

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Año de publicación:

2019

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Resumen:

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms.

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Los autores forman parte del International Helminth Genomes Consortium

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Editorial:

Nature Research

EN:

Nature Genetics, 2019, 51: 163-174

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Citación:

Coghlan, A, Cotton, J, Holroyd, N., y otros "Comparative genomics of the major parasitic worms". Nature Genetics. [en línea] 2019, 51: 163-174. 19 h. DOI: 10.1038/s41588-018-0262-1

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ISSN:

1546-1718

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones académicas y científicas
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10.1038s41588-018-0262-1.pdf — 2.47 MB Adobe PDF
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