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Título:

Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties

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Autor:

da Costa, Valeria
Mariño, Karina V.
Rodríguez-Zraquia, Santiago A.
Festari, María Florencia
Lores, Pablo
Costa, Monique
Landeira, Mercedes
Rabinovich, Gabriel A.
van Vliet, Sandra J.
Freire, Teresa

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Tipo de documento:

Artículo

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Palabras clave:

Lung cancer
Tn antigen
Macrophage galactose-type lectin
¨Dendritic cells
O-glycosylation

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NEOPLASIAS PULMONARES
MACRÓFAGOS
GALECTINAS
ANTÍGENOS
CÉLULAS DENDRÍTICAS
GLICOSILACIÓN
ACETILGALACTOSAMINA

Año de publicación:

2022

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Resumen:

Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc) linked to a serine or threonine residue in proteins (α-GalNAc-O-Ser/Thr). The Tn antigen can be recognized by the Macrophage Galactose/GalNAc lectin (MGL), which mediates various immune regulatory and tolerogenic functions, mainly by reprogramming the maturation of function of dendritic cells (DCs). In this work, we generated two different Tn-expressing variants from the Lewis-type lung murine cancer cell line LL/2, which showed different alterations in the O-glycosylation pathways that influenced the interaction with mouse MGL2 and the immunomodulatory properties of DCs. Thus, the identification of the biological programs triggered by Tn+ cancer cells might contribute to an improved understanding of the molecular mechanisms elicited by MGL-dependent immune regulatory circuits.

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MDPI

EN:

International Journal of Molecular Sciences. 2022;23(19)

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Citación:

da Costa V, Mariño K, Rodríguez-Zraquia S y otros. Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties. International Journal of Molecular Sciences [en línea]. 2022;23(19). 14 p.

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Licencia Creative Commons Atribución (CC - By 4.0)

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