Título:
Current developments of metaland metalloid-based quinoline compounds as leishmanicidal agents
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Autor:
Del Carpio, Edgar
Hernández, Lino
Lubes, Vito
Jourdan, Francisco
Cerecetto, Hugo
Scalese, Gonzalo
Gambino, Dinorah
Romero, Angel H.
Hernández, Lino
Lubes, Vito
Jourdan, Francisco
Cerecetto, Hugo
Scalese, Gonzalo
Gambino, Dinorah
Romero, Angel H.
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Tipo de documento:
Artículo
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Palabras clave:
Leishmaniasis
Leishmania
Ferroceno
Quinoleina
Carbenos N-heterociclicos
Leishmania
Ferroceno
Quinoleina
Carbenos N-heterociclicos
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Año de publicación:
2025
Contenido:
Resumen:
The quinoline moiety represents an important scaffold for the development of leishmanicidal agents. In particular, its hybridization with metal/metalloids has generated highly active compounds that are, in some cases, highly selective against leishmaniasis models. The existing leishmanicidal metal-/metalloidquinoline compounds are mainly based on the following: (i) coordination compounds based on 8-hydroxyquinolinate; (ii) metallocene derivatives; (iii) N-heterocyclic carbene (NHC) complexes featuring a quinoline moiety. This mini-review summarizes the reported cases of leishmanicidal metal and metalloid-based quinoline compounds for each group (i–iii), focusing on the structure-property relationship from in vitro Leishmania models and mechanisms of action, in vivo experiments, and pharmacokinetic data, if available. This paper aims to describe the state of the art of inorganic medicinal chemistry for the development of selective and potent leishmanicidal agents using the quinoline moiety.
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Frontiers
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Frontiers in Chemistry, v. 13,2025.--e1586044
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Citación:
Del Carpio, E., Hernández, L., Lubes, V. y otros. "Current developments of metaland metalloid-based quinoline compounds as leishmanicidal agents". Frontiers in Chemistry [en línea], v. 13,2025.--e1586044. 9 p.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Current developments.pdf | — | 2.24 MB | Adobe PDF |
Licencia Creative Commons:
Excepto donde se indique lo contrario, la licencia de este ítem se describe como Licencia Creative Commons Atribución (CC - By 4.0)