Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54527

Título:

Phages with a broad host range are common across ecosystems

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Autor:

Bignaud, Amaury
Conti, Devon
Thierry, Agnès
Serizay, Jacques
Labadie, Karine
Poulain, Julie
Cheny, Olivia
Colón-González, Maritrini
Debarbieux, Laurent
Guerrero-Osornio, Marianna
Helaine, Sophie
Hill, Peter
Le Tinier, Gwenaelle
Millot, Gael A.
Morales, Lucía
Parada, Andrés
Riera Faraone, Nadia
Iraola, Gregorio
Koszul, Roman
Marbouty, Martial

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Preprint

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Environmental microbiology
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Virology

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Año de publicación:

2025

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Resumen:

Phages are diverse and abundant within microbial communities, where they play major roles in their evolution and adaptation. Phage replication, and multiplication, is generally thought to be restricted within a single or narrow host range. Here we use published and newly generated proximity-ligation-based metagenomic Hi-C (metaHiC) data from various environments to explore virus–host interactions. We reconstructed 4,975 microbial and 6,572 phage genomes of medium quality or higher. MetaHiC yielded a contact network between genomes and enabled assignment of approximately half of phage genomes to their hosts, revealing that a substantial proportion of these phages interact with multiple species in environments as diverse as the oceanic water column or the human gut. This observation challenges the traditional view of a narrow host spectrum of phages by unveiling that multihost associations are common across ecosystems, with implications for how they might impact ecology and evolution and phage therapy approaches.

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Publicado también en: Nature Microbiology, 2025, 10: 2537–2549. DOI: 10.1038/s41564-025-02108-2

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HAL

EN:

HAL, 2025: pasteur-05269627.

Financiadores:

ANII: FSGSK_1_2019_1_15973

Citación:

Bignaud, A, Conti, D, Thierry, A [y otros autores]. "Phages with a broad host range are common across ecosystems" [Preprint]. Publicado en: HAL. 2025: pasteur-05269627. 42 h.

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Licencia Creative Commons Atribución (CC - By 4.0)

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