Título:
Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay
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Autor:
Pardo, Lorena
Vola, Magdalena
Macedo-Viñas, Marina
Machado, Virginia
Cuello, Dianna
Mollerach, Marta
Castro, Marta
Pírez, Catalina
Varela, Gustavo
Algorta, Gabriela
Vola, Magdalena
Macedo-Viñas, Marina
Machado, Virginia
Cuello, Dianna
Mollerach, Marta
Castro, Marta
Pírez, Catalina
Varela, Gustavo
Algorta, Gabriela
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Tipo de documento:
Artículo
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Palabras clave:
Staphylococcus aureus
methicillin resistance
pediatric diseases
Uruguay
methicillin resistance
pediatric diseases
Uruguay
Descriptores:
Año de publicación:
2013
Contenido:
Resumen:
Introduction: Staphylococcus aureus produces a variety of diseases among children, ranging from skin and soft tissue infections to invasive life-threatening diseases. Since 1990, an increasing number of diseases produced by community-associated methicillin-resistant S. aureus (CA-MRSA) isolates have been reported. The aim of this study was to describe the importance and the microbiological characteristics of S. aureus isolates recovered from children treated at the Hospital Pediátrico del Centro Hospitalario "Pereira Rossell” (HP-CHPR); focusing on invasive diseases caused by CA-MRSA isolates, as well as some clinical aspects of the diseases they have produced. Methodology: One hundred and twenty-five S. aureus isolates recovered from the HP-CHPR between 2003 and 2006 from children with invasive (n=89) and superficial diseases (n=36) were included. Genotypic and phenotypic characteristics of S. aureus isolates and relevant clinical aspects of each child were studied. Results: CA-MRSA isolates accounted for 73% of all S. aureus recovered from invasive (mainly bone and joint) infections, pneumonia and bacteraemia. The most common CA-MRSA strain recovered from invasive (n=65) and superficial (n=36) diseases had the following features: pulsotype A (type USA1100), SCCmec cassette type IV, Panton-Valentine Leukocidin genes positive, susceptibility to trimethoprim sulfamethoxazole without the inducible macrolide-lincosamide-streptogramin B (iMLSB) resistance phenotype. No association between genotypic characteristics of invasive CA-MRSA isolates and clinical outcomes was found. Conclusions: CA-MRSA isolates produced a wide spectrum of invasive diseases in a public paediatric hospital between 2003 and 2006. Microbiologic characterization suggests the spread of an adapted CA-MRSA clone lacking erm genes.
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EN:
J Infect Dev Ctries. 7(1), 2013
Financiadores:
Comisión Sectorial de Investigación Científica (CSIC)
Citación:
PARDO, L., VOLA, M., MACEDO-VIÑAS, M., y otros. Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay. J Infect Dev Ctries [en línea] 2013, 7(1). DOI: 10.3855/jidc.2261
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Cobertura geográfica:
Uruguay
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Community-associated methicillin-resistant Staphylococcus aureus in children treated in Uruguay.pdf | Artículo original | 556.22 KB | Adobe PDF |