Título:
Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
dos Santos, Jéssica Cristina
Moreno, María
Teufel, Lisa U.
Chilibroste, Sofía
Keating, Samuel T.
Groh, Laszlo
Domínguez-Andrés, Jorge
Williams, David L.
Ma, Zuchao
Lowman, Douglas W.
Ensley, Harry E.
Novakovic, Boris
Ribeiro-Dias, Fátima
Netea, Mihai G.
Chabalgoity, José A.
Joosten, Leo A.B.
Moreno, María
Teufel, Lisa U.
Chilibroste, Sofía
Keating, Samuel T.
Groh, Laszlo
Domínguez-Andrés, Jorge
Williams, David L.
Ma, Zuchao
Lowman, Douglas W.
Ensley, Harry E.
Novakovic, Boris
Ribeiro-Dias, Fátima
Netea, Mihai G.
Chabalgoity, José A.
Joosten, Leo A.B.
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Descriptores:
LEISHMANIA BRAZILIENSIS
MONOCYTES
MONOCYTES
Año de publicación:
2024
Contenido:
Resumen:
Innate immune cells can undergo long-term functional reprogramming after certain infections, a process called trained immunity (TI). Here, we focus on antigens of Leishmania braziliensis, which induced anti-tumor effects via trained immunity in human monocytes. We reveal that monocytes exposed to promastigote antigens of L. braziliensis develop an enhanced response to subsequent exposure to Toll-like receptor (TLR)2 or TLR4 ligands. Mechanistically, the induction of TI in monocytes by L. braziliensis is mediated by multiple pattern recognition receptors, changes in metabolism, and increased deposition of H3K4me3 at the promoter regions of immune genes. The administration of L. braziliensis exerts potent anti-tumor capabilities by delaying tumor growth and prolonging survival of mice with non-Hodgkin lymphoma. Our work reveals mechanisms of TI induced by L. braziliensis in vitro and identifies its potential for cancer immunotherapy.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
EN:
Cell Rep. 43, 2024
Financiadores:
Citación:
DOS SANTOS, JC., MORENO, M., TEUFEL, LU., y otros. Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity. Cell Rep [en línea] 2024, 43. DOI: 10.1016/j.celrep.2024.113932
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
ISMN:
Otros identificadores:
Cobertura geográfica:
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity.pdf | Artículo original | 4.36 MB | Adobe PDF |