Título:
Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?
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Autor:
Veloz, Lucía
Bosch Roascio, Santiago Alejandro
Aparicio Díaz, Hector Gonzalo
Zolessi, Flavio R.
Bosch Roascio, Santiago Alejandro
Aparicio Díaz, Hector Gonzalo
Zolessi, Flavio R.
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Epithelial-mesenchymal plasticity
Carcinoma
Neurulation
Neuroepithelium
Phosphorylation
Carcinoma
Neurulation
Neuroepithelium
Phosphorylation
Descriptores:
Año de publicación:
2022
Contenido:
Resumen:
Cell extrusion is an active mechanism to eliminate non-viable or supernumerary cells in healthy epithelia. It
also plays a role in carcinogenesis, both in tumor growth (apical extrusion) and metastasis (basal extrusion).
Embryonic tissues like the neuroepithelium, on the other hand, present rates of proliferation comparable to that of carcinomas, without the occurrence of cell extrusion. However, the downregulation or phosphorylation of actin
modulating proteins like MARCKS, causes extensive neuroepithelial apical cell extrusion. As changes in MARCKS proteins phosphorylation and expression have also been correlated to carcinogenesis, we propose here an integrated model for their functions in epithelial integrity.
Descripción:
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Editorial:
Tech Science Press
EN:
Biocell, 2022, 46(3): 639-644.
Financiadores:
CSIC: 125-347
Citación:
Veloz, L, Bosch Roascio, S, Aparicio Díaz, H [y otros autores]. "Cell extrusion in development and cancer, what MARCKS the difference for epithelial integrity?". Biocell. [en línea] 2022, 46(3): 639-644. 6 h. DOI: 10.32604/biocell.2022.018798
Citación:
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ISBN:
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ISSN:
1667-5746
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| TSP_BIOCELL_18798.pdf | — | 1.39 MB | Adobe PDF |