Título:
TRIM2, a novel member of the antiviral family, limits New World arenavirus entry
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Autor:
Sarute, Nicolás
Ibrahim, N.
Medegan Fagla, B.
Lavanya, M.
Cuevas, C.
Stavrou, S.
Otkiran-Clare, G.
Tyynismaa, H.
Henao-Mejia, J.
Ross, S. R.
Ibrahim, N.
Medegan Fagla, B.
Lavanya, M.
Cuevas, C.
Stavrou, S.
Otkiran-Clare, G.
Tyynismaa, H.
Henao-Mejia, J.
Ross, S. R.
Tutor:
Tipo de documento:
Artículo
Editor:
Rajsbaum, R.
Palabras clave:
Tripartite motif (TRIM)
New World arenaviruses
Virus infection
New World arenaviruses
Virus infection
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Año de publicación:
2019
Contenido:
Resumen:
Tripartite motif (TRIM) proteins belong to a large family with many roles in host biology, including restricting virus infection. Here, we found that TRIM2, which has been implicated in cases of Charcot–Marie–Tooth disease (CMTD) in humans, acts by blocking hemorrhagic fever New World arenavirus (NWA) entry into cells. We show that Trim2-knockout mice, as well as primary fibroblasts from a CMTD patient with mutations in TRIM2, are more highly infected by the NWAs Junı´n and Tacaribe virus than wild-type mice or cells are. Using mice with different Trim2 gene deletions and TRIM2 mutant constructs, we demonstrate that its antiviral activity is uniquely independent of the RING domain encoding ubiquitin ligase activity. Finally, we show that one member of the TRIM2 interactome, signal regulatory protein α (SIRPA), a known inhibitor of phagocytosis, also restricts NWA infection and conversely that TRIM2 limits phagocytosis of apoptotic cells. In addition to demonstrating a novel antiviral mechanism for TRIM proteins, these studies suggest that the NWA entry and phagocytosis pathways overlap
Descripción:
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Editorial:
Public Library of Science
EN:
PLoS Biology, 2019, 17(2): e3000137
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Citación:
Sarute, N, Ibrahim, N, Medegan Fagla, B, [y otros] "TRIM2, a novel member of the antiviral family, limits New World arenavirus entry". PLoS Biology. [en línea] 2019, 17(2): e3000137. 26 h. DOI: 10.1371/journal.pbio.3000137
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ISSN:
1545-7885
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1371journal.pbio.3000137.pdf | — | 3.04 MB | Adobe PDF |