Título:
Lethal and semi-lethal mutations in Holstein calves in Uruguay
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Autor:
Briano-Rodriguez, Carolina
Romero Benavente, Agustín
Llambí Dellacasa, Silvia
Branda Sica, Andrea
Federici, María Teresa
Giannitti, Federico
Caffarena, Rubén Darío
Schild, Carlos Omar
Casaux, María Laura
Dutra, Fernando
Romero Benavente, Agustín
Llambí Dellacasa, Silvia
Branda Sica, Andrea
Federici, María Teresa
Giannitti, Federico
Caffarena, Rubén Darío
Schild, Carlos Omar
Casaux, María Laura
Dutra, Fernando
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BOVINOS
PRODUCCION LECHERA
ENFERMEDADES HEREDITARIAS
MUTACION
TRASTORNOS GENETICOS
PRODUCCION LECHERA
ENFERMEDADES HEREDITARIAS
MUTACION
TRASTORNOS GENETICOS
Año de publicación:
2021
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Resumen:
Genetic disorders in Holstein cattle are a health problem that has grown worldwide in recent years, compromising the sustainability of modern dairy production. In Uruguay, Holstein-based milk production is one of the most important sectors of the country’s economy, but high levels of inbreeding have decreased the breed’s fertility in recent decades. This study investigated the presence and diffusion of lethal and semi-lethal alleles causing embryo death, abortions, fetal malformations, and neonatal diseases in Holstein calves. Using the GeneSeek® Genomic Profiler™ Bovine 50K BeadChip, we genotyped 383 calves (1–30 days-old) from 27 farms located in the main dairy region of Uruguay. Results showed a high prevalence of farms (85%) and carrier calves (21%), including one or more of the following semi-lethal or lethal alleles: Syndactylism (4.18%), brachyspina (3.39%), cholesterol deficiency haplotype (2.61%), complex vertebral malformation (2.09%), bovine leukocyte adhesion deficiency (1.04%s), and Holstein haplotypes HH1 (4.44%), HH3 (3.13%), HH4 (1.04%), and HH5 (0.26%). Most of these alleles had not been recognized previously in Uruguay. We concluded that lethal and semi-lethal mutations are widespread in the Holstein breed in Uruguay. More studies are required to determine their impact on dairy cattle fertility.
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Ciência Rural, 2021, 51(7), e20200734
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Briano-Rodriguez, C, Romero Benavente, A, Llambí Dellacasa, S, Branda Sica, A, Federici, M, Giannitti, F, Caffarena, R, Schild, C, Casaux, M y Dutra, F. Lethal and semi-lethal mutations in Holstein calves in Uruguay. Ciência Rural. [en línea] 2021, 51(7), e20200734.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| LL12.pdf | — | 812.25 KB | Adobe PDF |