Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/55471

Título:

Transcriptional Studies on Trypanosoma cruzi - Host Cell Interactions: A Complex Puzzle of Variables

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Autor:

Libisch, María Gabriela
Rego, Natalia
Robello, Carlos

Tutor:

Tipo de documento:

Artículo

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Palabras clave:

Chagas cardiomyopathy
Chagas disease
Trypanosoma cruzi
Experimental variables
Host-pathogen
Respiratory chain
Transcriptomics

Descriptores:

COMUNICACIÓN CELULAR
ENFERMEDAD DE CHAGAS
INTERACCIONES HUÉSPED-PARÁSITOS
HUMANOS
TRANSDUCCIÓN DE SEÑAL
TRANSCRIPTOMA
CARDIOMIOPATÍA CHAGÁSICA
TRANSPORTE DE ELECTRÓN

Año de publicación:

2021

Contenido:

Resumen:

Chagas Disease, caused by the protozoan parasite Trypanosoma cruzi, affects nearly eight million people in the world. T. cruzi is a complex taxon represented by different strains with particular characteristics, and it has the ability to infect and interact with almost any nucleated cell. The T. cruzi-host cell interactions will trigger molecular signaling cascades in the host cell that will depend on the particular cell type and T. cruzi strain, and also on many different experimental variables. In this review we collect data from multiple transcriptomic and functional studies performed in different infection models, in order to highlight key differences between works that in our opinion should be addressed when comparing and discussing results. In particular, we focus on changes in the respiratory chain and oxidative phosphorylation of host cells in response to infection, which depends on the experimental model of T. cruzi infection. Finally, we also discuss host cell responses which reiterate independently of the strain, cell type and experimental conditions.

Descripción:

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Editorial:

Frontiers Media

EN:

Frontiers in Cellular and Infection Microbiology. 2021;11

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Citación:

Libisch M, Rego N y Robello C. Transcriptional Studies on Trypanosoma cruzi - Host Cell Interactions: A Complex Puzzle of Variables. Frontiers in Cellular and Infection Microbiology [en línea]. 2021;11. 12 p.

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Licencia Creative Commons Atribución (CC - By 4.0)

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Publicaciones Académicas y Científicas
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Transcriptional Studies on Trypanosoma cruzi.pdf Transcriptional Studies on Trypanosoma cruzi 27.93 MB Adobe PDF
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