Título:
Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs
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Autor:
Pessina Serdio, Ana Paula
Castillo, Víctor Alejandro
César, D.
Sartore, I.
Meikle, Ana
Castillo, Víctor Alejandro
César, D.
Sartore, I.
Meikle, Ana
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Tipo de documento:
Artículo
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PERROS
PEQUEÑOS ANIMALES
GLANDULA TIROIDES
NEOPLASMAS
PEQUEÑOS ANIMALES
GLANDULA TIROIDES
NEOPLASMAS
Año de publicación:
2016
Contenido:
Resumen:
Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.
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Open Veterinary Journal, 2016, 6(3), 247-254
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Pessina Serdio, A, Castillo, V, César, D, Sartore, I y Meikle, A. Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs. Open Veterinary Journal. [en línea] 2016, 6(3), 247-254
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Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
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| M19.pdf | — | 516.68 KB | Adobe PDF |