Título:
Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: a pilot study
Otros títulos:
Coordinador:
Director:
Compilador:
Autor:
Cuña Rodríguez, Enrique Gustavo
Gambini, Juan Pablo
Servente, Liliana
Savio, Eduardo
Engler, Henry William
González Sprinberg, Gabriel A.
Alonso, Omar
Gambini, Juan Pablo
Servente, Liliana
Savio, Eduardo
Engler, Henry William
González Sprinberg, Gabriel A.
Alonso, Omar
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Gallgas
Quantification
Technegas
Texture features
Quantification
Technegas
Texture features
Descriptores:
Año de publicación:
2019
Contenido:
Resumen:
The aim of this study was quantitative comparison between 68Ga‑Gallgas positron emission tomography (PET) and 99mTc‑Technegas single photon emission computed tomography (SPECT) for lung ventilation function assessment in patients with moderate‑to‑severe obstructive pulmonary disease and to identify image‑derived texture features correlating to the physiologic parameters. Five patients with moderate‑to‑severe chronic obstructive pulmonary disease with PET and SPECT lung ventilation scans were selected for this study. Threshold‑based segmentations were used to compare ventilated regions between both imaging techniques. Histograms of both scans were compared to reveal main differences in distributions of radiotracers. Volumes of segmentation as well as 50 textural features measured in the pulmonary region were correlated to the forced expiratory volume in 1 s (FEV1) as the relevant physiological variable. A better peripheral distribution of the radiotracer was observed in PET scans for three out of five patients. A segmentation threshold of 27% and 31% for normalized scans, for PET and SPECT respectively, was found optimal for volume correlation with FEV1. A high correlation (Pearson correlation coefficient >0.9) was found between 16 texture features measured from SPECT and 7 features measured from PET and FEV1. Quantitative measurements revealed different tracer distribution in both techniques. These results suggest that tracer distribution patterns may depend on the cause of the pulmonary obstruction. We found several texture features measured from SPECT to correlate to FEV1.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
Wolters Kluwer - Medknow
EN:
World Journal of Nuclear Medicine, 2019, 18(3): 251-257
Financiadores:
Citación:
Cuña Rodríguez, E, Gambini, J, Servente, L, [y otros] "Quantitative comparison between single-photon emission computed tomography and positron emission tomography imaging of lung ventilation with 99mTc-technegas and 68Ga‑gallgas in patients with chronic obstructive pulmonary disease: A pilot study". World Journal of Nuclear Medicine. [en línea] 2019, 18(3): 251-257. 7 h. DOI: 10.4103/wjnm.WJNM_45_18
Citación:
metadata.articulos.cc.license.name:
ISBN:
e-ISBN:
ISSN:
1607-3312
ISMN:
Otros identificadores:
Cobertura geográfica:
Cobertura temporal:
Departamento académico:
Grupo de investigación:
Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.4103wjnm.WJNM_45_18.pdf | — | 2.18 MB | Adobe PDF |