Título:
Deep mutational scanning and CRISPR-engineered viruses: tools for evolutionary and functional genomics studies
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Autor:
Paz, Mercedes
Moratorio, Gonzalo
Moratorio, Gonzalo
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Deep mutational scanning
CRISPR-engineered viruses
Virus evolution
CRISPR-engineered viruses
Virus evolution
Descriptores:
Año de publicación:
2025
Contenido:
Resumen:
Recent advancements in synthetic biology and sequencing technologies have revolutionized the ability to manipulate viral genomes with unparalleled precision. This review focuses on two powerful methodologies: deep mutational scanning and CRISPR-based genome editing, that enable comprehensive mutagenesis and detailed functional characterization of viral proteins. These approaches have significantly deepened our understanding of the molecular determinants driving viral evolution and adaptation. Furthermore, we discuss how these advances provide transformative insights for future vaccine development and therapeutic strategies.
Descripción:
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Editorial:
American Society for Microbiology
EN:
mSphere, 2025, 10(5): e00508-24.
Financiadores:
Citación:
Paz, M y Moratorio, G. "Deep mutational scanning and CRISPR-engineered viruses: tools for evolutionary and functional genomics studies". mSphere. [en línea] 2025, 10(5): e00508-24. 14 h. DOI: 10.1128/msphere.00508-24
Citación:
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ISBN:
e-ISBN:
ISSN:
2379-5042
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1128.msphere.00508-24.pdf | — | 964.33 KB | Adobe PDF |