Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54288

Título:

Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay

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Autor:

Vásquez, Carolina
Gutierrez-Acevedo, María Nelly
Barbero, Sabrina
Notari, Lorena del Carmen
Agozino, Marina
Fernández, José Luis
Anders, María Margarita
Grigera, Nadia Lorena
Antinucci, Florencia
Orozco-Ganem, Orlando Nicolás Federico
Murga, María Dolores
Pérez, María Daniela
Palazzo, Ana Gracia
Martinez Rejtman, Liria
Duarte, Ivonne Giselle
Vorobioff, Julio Daniel
Trevizan, Victoria
Bulaty, Sofía
Bessone, Fernando
Valverde, Marcelo
Elizondo, Martín
Borzi, Silvia Mabel

Tutor:

Tipo de documento:

Artículo

Editor:

Palabras clave:

Antibiotics
Antimicrobial agents
Multidrug resistance

Descriptores:

ANTIBACTERIANOS
EPIDEMIOLOGÍA
USOS TERAPÉUTICOS
BACTERIAS
INFECCIONES BACTERIANAS
DIGNÓSTICO
ADMINISTRACIÓN DEL TRATAMIENTO FARMACOLÓGICO
INFECCIONES COMUNITARIAS ADQUIRIDAS
INFECCIÓN HOSPITALARIA
HUMANOS
CIRROSIS HEPÁTICA
ESTUDIOS PROSPECTIVOS
INFECCIONES URINARIAS

Año de publicación:

2023

Contenido:

Resumen:

Introduction and objectives: there is insufficient data regarding bacterial infections in patients with cirrhosis to support recommendations for empiric antibiotic treatments, particularly in Latin America. This study aimed to evaluate bacterial infection's clinical impact and microbiological characteristics, intending to serve as a platform to revise current practices. Materials and methods: multicenter prospective cohort study of patients with cirrhosis and bacterial infections from Argentina and Uruguay. Patient and infection-related information were collected, focusing on microbiology, antibiotic susceptibility patterns, and outcomes. Results: 472 patients were included. Spontaneous bacterial infections and urinary tract infections (UTIs) were registered in 187 (39.6%) and 116 (24.6%) patients, respectively, representing the most common infections. Of the 256 culture-positive infections, 103 (40.2%) were caused by multidrug-resistant organisms (reaching 50% for UTI), and 181 (70.7%) received adequate initial antibiotic treatment. The coverage of cefepime and ceftriaxone was over 70% for the empirical treatment of community-acquired spontaneous infections, but ceftazidime´s coverage was only 40%. For all UTI cases and for healthcare-associated or nosocomial spontaneous bacterial infections, the lower-spectrum antibiotics that covered at least 70% of the isolations were imipenem and meropenem. During hospitalization, a second bacterial infection was diagnosed in 9.8% of patients, 23.9% required at least one organ support, and 19.5% died. Conclusions: short-term mortality of bacterial infections in patients with cirrhosis is very high, and a high percentage were caused by multidrug-resistant organisms, particularly in UTIs. The information provided might serve to adapt recommendations, particularly related to empirical antibiotic treatment in Argentina and Uruguay. The study was registered in Clinical Trials (NCT03919032).

Descripción:

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Editorial:

Elsevier

EN:

Annals of Hepatology. 2023;28(4)

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Citación:

Vásquez C, Gutiérrez-Acevedo M, Barbero S y otros. Clinical and microbiological characteristics of bacterial infections in patients with cirrhosis. A prospective cohort study from Argentina and Uruguay. Annals of Hepatology [en línea]. 2023;28(4). 8 p.

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Cobertura geográfica:

ARGENTINA
URUGUAY

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Licencia:

Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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