Título:
Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice
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Autor:
Bascuas, Thais
Moreno, María
Grille, Sofía
Chabalgoity, José A.
Moreno, María
Grille, Sofía
Chabalgoity, José A.
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Artículo
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Palabras clave:
non-hodgkin lymphoma
chemotherapy
CHOP
Salmonella
immunotherapy
chemotherapy
CHOP
Salmonella
immunotherapy
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Año de publicación:
2018
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Resumen:
We have previously shown that Salmonella immunotherapy is effective to treat B-cell non-Hodgkin lymphoma (B-NHL) in mice. However, this model involves animals with high tumor burden, whereas in the clinics B-NHL patients are usually treated with chemotherapy (CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisone) as first-line therapy prior to immunotherapy. Recently, we have described a NHL-B preclinical model using CHOP chemotherapy to achieve MRD in immunocompetent animals that closely resemble patients’ conditions. In this work, we assessed the effi cacy of Salmonella immunotherapy in B-NHL-bearing mice undergoing chemotherapy. Salmonella administration significantly delayed tumor growth and prolonged survival of chemotherapy-treated NHL-bearing animals. Mice receiving the CHOP–Salmonella combined therapy showed increased numbers of tumor-infiltrating leukocytes and a different profile of cytokines and chemokines expressed in the tumor microenvironment. Further, Salmonella immunotherapy in CHOP-treated animals also enhanced NK cells cytotoxic activity as well as induced systemic lymphoma-specific humoral and cellular responses. Chemotherapy treatment profoundly impacted on the general health status of recipient animals, but those receiving Salmonella showed significantly better overall body condition. Altogether, the results clearly demonstrated that Salmonella immuno therapy could be safely used in individuals under CHOP treatment, resulting in a better prognosis. These results give strong support to consider Salmonella as a neoadjuvant therapy in a clinical setting.
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EN:
Front. Immunol. 9, 2018
Financiadores:
Agencia Nacional de Investigación e Innovación (ANII)
Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)
Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)
Citación:
BASCUAS, T., MORENO, M., GRILLE, S., y otros. Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice. Front. Immunol [en línea] 2018, 9. DOI: 10.3389/fimmu.2018.00007
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice.pdf | Artículo original | 2.07 MB | Adobe PDF |