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Título:

Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review

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Autor:

González González, Rogelio
López-Verdín, Sandra
Lavalle-Carrasco, Jesús
Molina-Frechero, Nelly
Isiordia-Espinoza, Mario Alberto
Carreón Burciaga, Ramón Gil
Bologna-Molina, Ronell

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Artículo

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Palabras clave:

Ameloblastoma
B-raf proto-oncogene serine/threonine kinase
B-raf protooncogene serine/threonine kinase V600E
Targeted therapies
Additional mutations

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Año de publicación:

2020

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Resumen:

Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies. Different signaling pathways that participate in the progression of these tumors have been identified. B-raf proto-oncogene serine/threonine kinase (BRAF) is a protein involved in the behavior of ameloblastomas, and it is related to many cell mechanisms. BRAF gene mutations have been identified in ameloblastomas, of which the BRAF V600E (valine substituted by glutamic acid at amino acid 600) mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior. Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.

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EN:

World Journal Clinical Oncology, January 24; 11(1): 31-42, 2020

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Citación:

González González, R, López-Verdín, S, Lavalle-Carrasco, J, y otros. "Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review". World Journal Clinical Oncology. [en línea] January 24; 11(1): 31-42, 2020. DOI: 10.5306/wjco.v11.i1.31

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2218-4333 (online)

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Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)

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Publicaciones académicas y científicas 2020-
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