Título:
Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m
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Compilador:
Autor:
Teixeira, Vania
Cabral González, Pablo
Porcal, Williams
Cabral González, Pablo
Porcal, Williams
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Chelation
Hydrazone
HYNIC
Microwave
Solid-phase
Technetium-99m
Hydrazone
HYNIC
Microwave
Solid-phase
Technetium-99m
Descriptores:
Año de publicación:
2018
Contenido:
Resumen:
We report a new method for efficient and rapid synthesis of HYNIC-hydrazone derivatives using microwaveassisted solid-phase. In comparison to the conventional heating procedure, microwave irradiation considerably accelerated the formation of HYNIC analogues. The synthesis time and efforts are significantly reduced in the present method, without side product formation. We proved that the HYNIC-hydrazone clustering can be directly labeled with technetium without exposing the free hydrazine group. Therefore, this is a useful tool to obtain HYNIC-bioconjugates for use in 99mTc radiochemistry.
Descripción:
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Editorial:
Arkat
EN:
Arkivoc, 2018, (5), pp. 29-38.
Financiadores:
Citación:
Teixeira, V, Cabral González, P y Porcal, W. "Microwave-assisted solid-phase synthesis of nicotinyl hydrazones for use in radiochemistry of technetium-99m". Arkivoc. [en línea] 2018, (5), pp. 29-38. 10 h. doi: 10.24820/ark.5550190.p010.065
Citación:
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ISBN:
e-ISBN:
ISSN:
1551-7004
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 1024820ark5550190p010065.pdf | — | 1.29 MB | Adobe PDF |