Título:
Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle
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Autor:
Jara, Eugenio
Peñagaricano, Francisco
Armstrong, Eileen
Menezes, Claudia
Tardiz, Lucía
Rodons, Gastón
Iriarte, Andrés
Peñagaricano, Francisco
Armstrong, Eileen
Menezes, Claudia
Tardiz, Lucía
Rodons, Gastón
Iriarte, Andrés
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Tipo de documento:
Artículo
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Palabras clave:
Beef cattle
Eye cancer
lncRNAs
Noncoding genetic elements
Strand-specific RNAseq
Eye cancer
lncRNAs
Noncoding genetic elements
Strand-specific RNAseq
Descriptores:
GENÉTICA
BOVINOS
ANIMALES
NEOPLASIAS DEL OJO
ARN LARGO NO CODIFICANTE
BOVINOS
ANIMALES
NEOPLASIAS DEL OJO
ARN LARGO NO CODIFICANTE
Año de publicación:
2022
Contenido:
Resumen:
Several ocular pathologies in cattle, such as ocular squamous cell carcinoma and infectious keratoconjunctivitis, have been associated with low pigmentation of the eyelids. The main objective of this study was to analyze the transcriptome of eyelid skin in Hereford cattle using strand-specific RNA sequencing technology to characterize and identify long noncoding RNAs (lncRNAs). We compared the expression of lncRNAs between pigmented and unpigmented eyelids and analyzed the interaction of lncRNAs and putative target genes to reveal the genetic basis underlying eyelid pigmentation in cattle. We predicted 4,937 putative lncRNAs mapped to the bovine reference genome, enriching the catalog of lncRNAs in Bos taurus. We found 27 differentially expressed lncRNAs between pigmented and unpigmented eyelids, suggesting their involvement in eyelid pigmentation. In addition, we revealed potential links between some significant differentially expressed lncRNAs and target mRNAs involved in the immune response and pigmentation. Overall, this study expands the catalog of lncRNAs in cattle and contributes to a better understanding of the biology of eyelid pigmentation.
Descripción:
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Editorial:
Frontiers Media
EN:
Frontiers in Genetics. 2022;13
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Citación:
Jara E, Peñagaricano F, Armstrong E y otros. Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle. Frontiers in Genetics [en línea]. 2022;13. 12 p.
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Identification of Long Noncoding RNAs.pdf | Identification of Long Noncoding RNAs | 24.17 MB | Adobe PDF |