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Título:

A deletion in SARS-CoV- 2 ORF7 identified in COVID-19 outbreak in Uruguay

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Autor:

Panzera Crespo, Yanina
Ramos, Natalia
Frabasile Giurato, Sandra Alicia
Calleros Basilio, Lucía
Marandino, Ana
Tomás Custodio, Gonzalo Martín
Techera, Claudia
Grecco Patiño, Sofía
Fuques Villalba, Eddie
Goñi Mazzitelli, Natalia
Ramas, Vivivana
Coppola, Leticia
Chiparelli, Héctor
Sorhouet, Cecilia
Mogdasy, Cristina
Arbiza, Juan
Delfraro Vázquez, Adriana Beatriz
Pérez Crossa, Ruben Gustavo

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Artículo

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Palabras clave:

SARS-CoV- 2
ORF7a

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Año de publicación:

2021

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Resumen:

The analysis of genetic diversity in SARS-CoV-2 is the focus of several studies, providing insights into how the virus emerged and evolves. Most common changes in SARS-CoV-2 are single or point nucleotide substitutions; meanwhile, insertions and deletions (indels) have been identified as a less frequent source of viral genetic variability. Here, we report the emergence of a 12-nucleotide deletion in ORF7a, resulting in a 4-amino acid in-frame deletion. The Δ12 variant was identified in viruses from patients of a single outbreak and represents the first report of this deletion in South American isolates. Phylogenetic analysis revealed that Δ12 strains belong to the lineage B.1.1 and clustered separated from the remaining Uruguayan strains. The ∆12 variant was detected in 14 patients of this outbreak by NGS sequencing and/or two rapid and economic methodologies: Sanger amplicon sequencing and capillary electrophoresis. The presence of strong molecular markers as the deletion described here are useful for tracking outbreaks and reveal a significant aspect of the SARS-CoV-2 evolution on the robustness of the virus to keep its functionality regardless loss of genetic material.

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Willey

EN:

Transboundary and Emerging Diseases, 2021, 68(6): 3075-3082.

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Citación:

Panzera Crespo, Y, Ramos, N, Frabasile Giurato, S [y otros autores]. "A deletion in SARS-CoV- 2 ORF7 identified in COVID-19 outbreak in Uruguay". Transboundary and Emerging Diseases. [en línea] 2021, 68(6): 3075-3082. 8 h. DOI: 10.1111/tbed.14002.

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1865-1682

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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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