Título:
4-Aminoquinoline: a comprehensive review of synthetic strategies
Otros títulos:
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Director:
Compilador:
Autor:
Delgado Pelayo, Francisco Javier
Benítez, Andrés
Gotopo, Lourdes
Romero Cordero, Ángel Heriberto
Benítez, Andrés
Gotopo, Lourdes
Romero Cordero, Ángel Heriberto
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
4-aminoquinoline
4,7-dichloroquinoline
SNAr
Annulation
Ulmann activation
Oxidative dehydrogenation
4,7-dichloroquinoline
SNAr
Annulation
Ulmann activation
Oxidative dehydrogenation
Descriptores:
Año de publicación:
2025
Contenido:
Resumen:
4-Aminoquinoline is an important scaffold due to its variety of applications in medicinal, synthetic organic, and industrial chemistry. It has gained great relevance for the development of selective and potent leishmanicidal agents
targeting parasite mitochondria, agonists and antagonists of Toll-like receptors (TLRs), antimalarials, and anticancer agents. As a consequence of the importance of 4-aminoquinoline as leishmanicidal, the present mini-review article aims to give comprehensive information about the different synthetic alternatives for the synthesis of 4-aminoquinolines, including (i) reactions based on nucleophilic aromatic substitution via conventional heating, microwave, and ultrasound; (ii) one-pot metal-free or metal-catalyzed reactions of inter- and intramolecular
cyclization/annulation; (iii) miscellaneous reactions including the dehydrogenative amination of dihydroquinolin-4(1H)one and amination via Hartwig–Buchwald cross-coupling or rearrangement reactions.
Descripción:
metadata.articulos.dc.description.uri:
Editorial:
Frontiers
EN:
Frontiers in Chemistry, 2025, 13: 1553975.
Financiadores:
ANII: SNI_2023_1_1013178
Citación:
Delgado Pelayo, F, Benítez, A, Gotopo, L [y otro autor]. "4-Aminoquinoline: a comprehensive review of synthetic strategies". Frontiers in Chemistry. [en línea] 2025, 13: 1553975. 8 h. DOI: 10.3389/fchem.2025.1553975
Citación:
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e-ISBN:
ISSN:
2296-2646
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.3389.fchem.2025.1553975.pdf | — | 957.35 KB | Adobe PDF |