Título:
Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy
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Apellániz de los Campos, Delmira
Pereira-Prado, Vanesa
Sicco, Estefanía
Vigil Bastitta, Gabriela
González González, Rogelio
Mosqueda Taylor, Adalberto
Molina-Frechero, Nelly
Hernández, M.
Sánchez Romero, C.
Pereira-Prado, Vanesa
Sicco, Estefanía
Vigil Bastitta, Gabriela
González González, Rogelio
Mosqueda Taylor, Adalberto
Molina-Frechero, Nelly
Hernández, M.
Sánchez Romero, C.
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Artículo
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PRURIGO
Año de publicación:
2018
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Resumen:
Actinic prurigo (AP) is an idiopathic photodermatosis; the initial manifestations usually occur during the first decades of life but can appear at any age. Cases are usually diagnosed late once the lesions have exacerbated; due to the extensive involvement of the vermilion border and the etiology, it has been confused with and related to a potentially malignant process. Syndecan-1 and E-cadherin were positive in the epidermis, with moderate-to-intense staining in 100% of samples. Ki67 and MCM3 were expressed in the lower third of the epidermis and showed greater immunolabeling in samples that contained lymphoid follicles (Ki 67: epidermis [17.7% ± 6.79%] and dermis [7.73% ± 6.69%]; MCM3: epidermis [22.92% ± 10.12%] and dermis [6.13% ± 6.27%]). In conclusión AP is a disease in which there is no evidence that the lesions are potentially cancerous. AP cheilitis should not be confused with actinic cheilitis because they are separate entities.
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Wolters Kluwer - Medknow
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Indian journal of pathology & microbiology, 2018 (61) 2: 225--227
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Citación:
Mancheno-Valencia A, Bologna-Molina RE, Toussaint-Caire S, Vega-Memije ME, Cuevas-González JC. Expression of E-cadherin, syndecan 1, Ki-67, and maintenance minichromosome 3 in tissue lesions of actinic prurigo obtained by incisional biopsy. Indian J Pathol Microbiol 2018;61:225-227.
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0377-4929
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