Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54289

Título:

Blood pressure and cardiovascular risk in relation to birth weight and urinary sodium: an individual-participant meta-analysis of European family-based population studies

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Autor:

Yu, Yu-Ling
Moliterno, Paula
De-Wei, An
Raaijmakers, Anke
Martens, Dries S.
Stolarz-Skrzypek, Katarzyna
Tikhonoff, Valérie
Malyutina, Sofía
Casiglia, Edoardo
Chori, Babangida
Filipovský, Jan
Rajzer, Marek
Allegaert, Karel
Kawecka-Jaszcz, Kalina
Verhamme, Peter
Nawrot, Tim S.
Staessen, Jan A.
Boggia, José

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Tipo de documento:

Artículo

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Palabras clave:

Birth weight
Cardiovascular risk
Hypertension
Total mortality
Urinary sodium excretion

Descriptores:

ADULTOS
PESO AL NACER
PRESIÓN ARTERIAL
FISIOLOGÍA
ENFERMEDADES CARDIOVASCULARES
FACTORES DE RIESGO DE ENFERMEDAD CARDIACA
HIPERTENSIÓN
SODIO

Año de publicación:

2023

Contenido:

Resumen:

Background: Although the relation of salt intake with blood pressure (BP) is linear, it is U-shaped for mortality and cardiovascular disease (CVD). This individual-participant meta-analysis explored whether the relation of hypertension, death or CVD with 24-h urinary sodium excretion (UVNA) or sodium-to-potassium (UNAK) ratio was modified by birth weight. Methods: Families were randomly enrolled in the Flemish Study on Genes, Environment and Health Outcomes (1985-2004) and the European Project on Genes in Hypertension (1999-2001). Categories of birth weight, UVNA and UNAK (≤2500, >2500-4000, >4000 g; <2.3, 2.3-4.6 and >4.6 g; and <1, 1-2, >2, respectively) were coded using deviation-from-mean coding and analyzed by Kaplan-Meier survival functions and linear and Cox regression. Results: The study population was subdivided into the Outcome ( n = 1945), Hypertension ( n = 1460) and Blood Pressure cohorts ( n = 1039) to analyze the incidence of mortality and cardiovascular endpoints, hypertension and BP changes as function of UVNA changes. The prevalence of low/medium/high birth weight in the Outcome cohort was 5.8/84.5/9.7%. Over 16.7 years (median), rates were 4.9, 8 and 27.1% for mortality, CVD and hypertension, respectively, but were not associated with birth weight. Multivariable-adjusted hazard ratios were not significant for any endpoint in any of the birth weight, UVNA and UNAK strata. Adult body weight tracked with birth weight ( P < 0.0001). The partial r in the low-birth-weight group associating changes from baseline to follow-up in UVNA and SBP was 0.68 ( P = 0.023) but not significant in other birth weight groups. Conclusion: This study did not substantiate its prior hypothesis but showed tracking of adult with birth weight and suggest that low birth weight increases salt sensitivity.

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Lippincott, Williams & Wilkins

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Journal of hypertension. 2023;41(7):1175-1183

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Citación:

Yu Y, Moliterno P, De-Wei A y otros. Blood pressure and cardiovascular risk in relation to birth weight and urinary sodium: an individual-participant meta-analysis of European family-based population studies. Journal of hypertension [en línea]. 2023;41(7):1175-1183

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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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