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Título:

Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification

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Autor:

Sethi, Sanjeev M.
Beck, Laurence H.
Glassock, Richard J.
Haas, Mark
de Vriese, An Sabine P.
Caza, Tiffany N.
Hoxha, Elion
Lambeau, Gérard
Tomas, Nicola M.
Madden, Benjamin
Debiec, Hanna
D'Agati, Vivette D.
Alexander, Mariam P.
Amer, Hatem
Appel, Gerald B.
Barbour, Sean J.
Caravaca-Fontán, Fernando
Cattran, Daniel C.
Casal Moura, Marta
D’Avila, Domingos O.
Fervenza, Fernando C.
Yandian, Federico

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Descriptores:

GLOMERULONEFRITIS MEMBRANOSA
COMPLEJO ANTÍGENO-ANTICUERPO
MEMBRANA BASAL GLOMERULAR
TÉCNICA DEL ANTICUERPO FLUORESCENTE
INMUNOHISTOQUÍMICA
ANTICUERPOS
PATOLOGÍA
TERAPÉUTICA
DIAGNÓSTICO
NEFRECTOMÍA
RECEPTORES DE FOSFOLIPASA A2

Año de publicación:

2023

Contenido:

Resumen:

Membranous nephropathy (MN)is a pattern of injury caused by autoantibodies binding to specifictarget antigens, with accumulation of immunecomplexes alongthe subepithelial region of glomerular basement membranes. The past 20 years have brought revolutionary advances in the understanding of MN, particularly via the discovery of novel target antigens and their respective auto antibodies. These discoveries have challenged the traditional classification of MN into primary and secondary forms. At least 14 target antigens have been identified, accounting for 80%e90% of cases of MN. Many of the forms of MN associated with these novel MNtarget antigens have distinctive clinical and pathologic phenotypes. The Mayo Clinic consensus report on MN proposes a 2-step classification of MN. The first step, when possible, is identification of the target antigen, based on a multistep algorithm and using a combination of serology, staining of the kidney biopsy tissue by immunofluorescence or immunohistochemistry, and/or mass spectrometry methodology. The second step is the search for a potential underlying disease or associated condition, which is particularly relevant when knowledge of the target antigen is available to direct it. The meeting acknowledges that there sources and equipment required to perform the proposed testing may not be generally available. However, the meeting consensus was that the time has come to adopt an antigenbased classification of MN because this approach will allow for accurate and specific MN diagnosis, with significant implications for patient management and targeted treatment.

Descripción:

Renato G. Eick MD, Vesna D. Garovic MD, PhD, Eddie L. Greene MD, Loren P. Herrera Hernandez MD, J. Charles Jennette MD, John C. Lieske MD, Glen S. Markowitz MD, Karl A. Nath MB, ChB, Samih H. Nasr MD, Cynthia C. Nast MD, Antonello Pani MD, Manuel Praga MD, Giuseppe Remuzzi MD, Helmut G. Rennke MD, Piero Ruggenenti MD, Dario Roccatello MD, Maria Jose Soler MD, PhD, Ulrich Specks MD, Rolf A.K. Stahl MD, Raman Deep Singh PhD, Jason D. Theis BS, Jorge A. Velosa MD, Jack F.M. Wetzels MD, Christopher G. Winearls MD, Ladan Zand MD, Pierre Ronco MD.

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Editorial:

Elsevier

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Mayo Clinic Proceedings. 2023;98(11):1671-1684

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Citación:

Sethi S, Beck L, Glassock R y otros. Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification. Mayo Clinic Proceedings [en línea]. 2023;98(11):1671-1684

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Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)

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