| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Pardo, Lorena | - |
| dc.contributor.author | Autor | Mota, María Inés | - |
| dc.contributor.author | Autor | Parnizari, Andrés | - |
| dc.contributor.author | Autor | Varela, Adriana | - |
| dc.contributor.author | Autor | Algorta, Gabriela | - |
| dc.contributor.author | Autor | Varela, Gustavo | - |
| dc.contributor.filiacion | Filiación | Pardo Lorena, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
| dc.contributor.filiacion | Filiación | Mota María Inés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
| dc.contributor.filiacion | Filiación | Parnizari Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
| dc.contributor.filiacion | Filiación | Varela Adriana, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio Bacteriología | - |
| dc.contributor.filiacion | Filiación | Algorta Gabriela, Administración de los Servicios de Salud del Estado (ASSE) (Uruguay). Centro Hospitalario Pereira Rossell. Laboratorio Bacteriología | - |
| dc.contributor.filiacion | Filiación | Varela Gustavo, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene. Unidad Académica Bacteriología y Virología | - |
| dc.date.accessioned | Fecha ingreso | 2025-11-14T15:41:32Z | - |
| dc.date.available | Fecha disponible | 2025-11-14T15:41:32Z | - |
| dc.date.issued | Año de publicación | 2024 | - |
| dc.description.abstract | Resumen | Vancomycin is the cornerstone in treating methicillin-resistant Staphylococcus aureus (MRSA) infections. However, therapeutic failures can occur when MRSA strains with decreased susceptibility to glycopeptides (DSG) are involved. The aim of this study was to detect and characterize DSG in MRSArecovered from children with invasive diseases at a reference pediatric hospital between 2009 and2019. Fifty-two MRSAstrains werescreenedusingagarplates with vancomycin3 and 4 mg/L (BHI-3 and BHI-4); the VITEK2 system; and standard and macro E-tests. Suspicious hVISA were studied by population analysis profiling–area under the curve (PAP-AUC), and wall thickness was analyzed by transmission electron microscopy. Neither VRSA nor VISA were detected in this set. As only three strains met the hVISA criteria, the PAP-AUC study included 12 additional MRSA strains that grew one colony on BHI-4 plates or showed minimum inhibitory concentrations of vancomycin and/or teicoplanin 1.5 mg/L. One strain was confirmed as hVISA by PAP-AUC. The wall thickness was greater than the vancomycin-susceptible control strain; it belonged to ST30 and carried SCCmec IV. As expected, a low frequency of hVISA was found (1.9%). The only hVISA confirmed by PAP-AUC wasnot detected by the screening methods, highlighting the challenge that its detection represents for microbiology laboratories. | es |
| dc.description.sponsorship | Financiadores | Comisión Sectorial de Investigación Científica (CSIC) | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | PARDO, L., MOTA, MI., PARNIZARI, A., y otros. Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital. Antibiotics [en línea] 2024, 13. DOI: 10.3390/antibiotics13040298 | es |
| dc.identifier.doi | DOI | 10.3390/antibiotics13040298 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/52464 | - |
| dc.language.iso | Idioma | en | es |
| dc.relation.ispartof | EN | Antibiotics. 13, 2024 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución (CC - By 4.0) | es |
| dc.subject | Palabras clave | S. aureus | es |
| dc.subject | Palabras clave | vancomycin resistance | es |
| dc.subject | Palabras clave | methicillin-resistant Staphylococcus aureus | es |
| dc.subject | Palabras clave | hVISA | es |
| dc.title | Título | Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Detection of Vancomycin Resistance among Methicillin-Resistant Staphylococcus aureus Strains Recovered from Children with Invasive Diseases in a Reference Pediatric Hospital.pdf | Artículo original | 3.23 MB | Adobe PDF |