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dc.contributor.author Autor Zócalo, Yanina-
dc.contributor.author Autor Bia, Daniel-
dc.contributor.filiacion Filiación Zócalo Yanina, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Fisiología y Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE)-
dc.contributor.filiacion Filiación Bia Daniel, Universidad de la República (Uruguay). Facultad de Medicina. Departamento de Fisiología y Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE)-
dc.date.accessioned Fecha ingreso 2026-05-27T16:10:43Z-
dc.date.available Fecha disponible 2026-05-27T16:10:43Z-
dc.date.issued Año de publicación 2022-
dc.description.abstract Resumen Aortic blood pressure (aoBP) waveform-derived indexes could provide valuable (prognostic) information over and above cardiovascular risk factors (CRFs). To obtain aoBP waveform-characteristics, several (i) techniques, (ii) recording sites, (iii) pressure-only waveform analysis mathematical approaches [e.g., pulse wave analysis (PWA), wave separation analysis (WSA)], and (iv) indexes [augmentation pressure and index (AP and AIx), forward (Pf) and backward (Pb) components of aoBP, reflection magnitude (RM), and reflection index (Rix)], were proposed. An accurate clinical use of these indexes requires knowing their physiological age-related profiles and the expected values for a specific subject. There are no works that have characterized waveform-derived indexes profiles in large populations considering: (i) as a continuous, data from different age stages (childhood, adolescence, and adulthood), (ii) complementary indexes, (iii) data obtained from different techniques and approaches, and (iv) analyzing potential sex- and body height (BH)-related differences. In addition, (v) there is a lack of normative data (reference intervals, RIs) for waveform-derived indexes. Aims: (1) to evaluate the association and agreement between PWA- and/or WSA-derived indexes obtained with different techniques and approaches; (2) to determine the need for sex-, BH-, and/or age-specific RIs; (3) to define RIs for PWA- and WSA-derived indexes in a large cohort of healthy children, adolescents, and adults. Methods: 3619 subjects (3-90 y) were included; 1688 healthy (2-84 y). AP, AIx, AIx@75, Pf, Pb, RM, and RIx were obtained (carotid and radial tonometry, brachial oscillometry/plethysmography). The association and agreement between indexes were analyzed (Concordance correlation coefficients, Bland-Altman analysis). Mean and SD equations and sex-specific BH- and age-related profiles were obtained (regression methods; fractional polynomials). Results: Waveform-derived indexes were not equivalent; for a specific index, there were systematic and proportional differences associated with the recording site (e.g., carotid vs. radial) and technique (e.g., tonometry vs. oscillometry). The need for sex-, BH-, or age-specific RIs was dependent on the index and/or age considered. RIs were defined for each index considering differences between recording sites and techniques. Equations for waveform-derived indexes age-related profiles were included, enabling to determine for a specific subject, the expected values and potential data deviations.es
dc.format.extent Extensión 22 p.es
dc.format.mimetype Formato application/pdfes
dc.identifier.citation Citación Zócalo Y y Bia D. Central Pressure Waveform-Derived Indexes Obtained From Carotid and Radial Tonometry and Brachial Oscillometry in Healthy Subjects (2-84 Y): Age-, Height-, and Sex-Related Profiles and Analysis of Indexes Agreement. Frontiers in Physiology [en línea]. 2022;12. 22 p.es
dc.identifier.doi DOI 10.3389/fphys.2021.774390-
dc.identifier.eissn e-ISSN 1664-042X-
dc.identifier.uri URI https://hdl.handle.net/20.500.12008/55231-
dc.language.iso Idioma enes
dc.publisher Editorial Frontiers Mediaes
dc.relation.ispartof EN Frontiers in Physiology. 2022;12es
dc.rights Derechos Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014)es
dc.rights.licence Licencia Licencia Creative Commons Atribución (CC - By 4.0)es
dc.subject Palabras clave Applanation tonometryes
dc.subject Palabras clave Adolescentses
dc.subject Palabras clave Childrenes
dc.subject Palabras clave Adultses
dc.subject Palabras clave Normative dataes
dc.subject Palabras clave Oscillometryes
dc.subject Palabras clave Pulse wave analysises
dc.subject Palabras clave Wave separation analysises
dc.subject.other Descriptores OSCILOMETRÍAes
dc.subject.other Descriptores ANÁLISIS DE LA ONDA DEL PULSOes
dc.subject.other Descriptores NIÑOes
dc.subject.other Descriptores ADULTOes
dc.subject.other Descriptores ADOLESCENTEes
dc.subject.other Descriptores MANOMETRÍAes
dc.title Título Central Pressure Waveform-Derived Indexes Obtained From Carotid and Radial Tonometry and Brachial Oscillometry in Healthy Subjects (2-84 Y): Age-, Height-, and Sex-Related Profiles and Analysis of Indexes Agreementes
dc.type Tipo de documento Artículoes

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