Título:
Stage-specific transcriptomic analysis of the model cestode Hymenolepis microstoma
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Autor:
Preza, Matías
Calvelo, Javier
Langleib, Mauricio
Hoffmann, Federico
Castillo, Estela
Koziol, Uriel
Iriarte, Andrés
Calvelo, Javier
Langleib, Mauricio
Hoffmann, Federico
Castillo, Estela
Koziol, Uriel
Iriarte, Andrés
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Tipo de documento:
Artículo
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Palabras clave:
Tapeworm
RNA-seq
Flatworms functional genomics
Gene family evolution
Antigen B
RNA-seq
Flatworms functional genomics
Gene family evolution
Antigen B
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Año de publicación:
2021
Contenido:
Resumen:
Most parasitic flatworms go through different life stages with important physiological and morphological changes. In this work, we used a transcriptomic approach to analyze the main life-stages of the model tapeworm Hymenolepis microstoma (eggs, cysticercoids, and adults). Our results showed massive transcriptomic changes in this life cycle, including key gene families that contribute substantially to the expression load in each stage. In particular, different members of the cestode-specific hydrophobic ligand-binding protein (HLBP) family are among the most highly expressed genes in each life stage. We also found the transcriptomic signature of major metabolic changes during the transition from cysticercoids to adult worms. Thus, this work contributes to uncovering the gene expression changes that accompany the development of this important cestode model species, and to the best of our knowledge represents the first transcriptomic study with robust replicates spanning all of the main life stages of a tapeworm.
Descripción:
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EN:
Genomics. 113(2), 2021
Financiadores:
Agencia Nacional de Investigación e Innovación (ANII)
Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)
Programa de Desarrollo de las Ciencias Básicas (PEDEClBA)
Citación:
PREZA, M., CLAVELO, J., LANGLEIB, M., y otros. Stage-specific transcriptomic analysis of the model cestode Hymenolepis microstoma. Genomics [en línea] 2021, 113(2). DOI: 10.1016/j.ygeno.2021.01.005
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Licencia:
Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Stage-specific transcriptomic analysis of the model cestode Hymenolepis microstoma.pdf | Artículo original | 6.38 MB | Adobe PDF |