| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Rodríguez Duarte, Jorge | es |
| dc.contributor.author | Autor | Dapueto Capuccio, Rosina | es |
| dc.contributor.author | Autor | Galliussi, Germán | es |
| dc.contributor.author | Autor | Turell Novo, Lucía | es |
| dc.contributor.author | Autor | Kamaid Toth, Andrés | es |
| dc.contributor.author | Autor | Khoo, N. K. H. | es |
| dc.contributor.author | Autor | Schopfer, F.J. | es |
| dc.contributor.author | Autor | Freeman, B.A. | es |
| dc.contributor.author | Autor | Escande, Carlos | es |
| dc.contributor.author | Autor | Batthyány Dighiero, Carlos | es |
| dc.contributor.author | Autor | Ferrer-Sueta, Gerardo | es |
| dc.contributor.author | Autor | López, Gloria V. | es |
| dc.contributor.filiacion | Filiación | Rodríguez Duarte, Jorge. Instituto Pasteur (Montevideo) | es |
| dc.contributor.filiacion | Filiación | Dapueto Capuccio, Rosina. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
| dc.contributor.filiacion | Filiación | Galliussi, Germán. Instituto Pasteur (Montevideo) | es |
| dc.contributor.filiacion | Filiación | Turell Novo, Lucía. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
| dc.contributor.filiacion | Filiación | Kamaid Toth, Andrés. Instituto Pasteur (Montevideo) | es |
| dc.contributor.filiacion | Filiación | Escande Castro, Carlos José. Instituto Pasteur (Montevideo) | es |
| dc.contributor.filiacion | Filiación | Batthyany Dighiero, Carlos. Instituto Pasteur (Montevideo) | es |
| dc.contributor.filiacion | Filiación | Ferrer Sueta, Gerardo. Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología | es |
| dc.contributor.filiacion | Filiación | López, Gloria V. Instituto Pasteur (Montevideo) | es |
| dc.date.accessioned | Fecha ingreso | 2019-10-02T22:08:21Z | - |
| dc.date.available | Fecha disponible | 2019-10-02T22:08:21Z | - |
| dc.date.issued | Año de publicación | 2018 | es |
| dc.date.submitted | Fecha de subida | 20190930 | es |
| dc.description.abstract | Resumen | Inflammation plays a major role in the onset and development of chronic non-communicable diseases like obesity, cardiovascular diseases and cancer. Combined, these diseases represent the most common causes of death worldwide, thus development of novel pharmacological approaches is crucial. Electrophilic nitroalkenes derived from fatty acids are formed endogenously and exert anti-inflammatory actions by the modification of proteins involved in inflammation signaling cascades. We have developed novel nitroalkenes derived from α-tocopherol aiming to increase its salutary actions by adding anti-inflammatory properties to a well-known nutraceutical. We synthesized and characterized an α-tocopherol-nitroalkene (NATOH) and two hydrosoluble analogues derived from Trolox (NATxME and NATx0). We analyzed the kinetics of the Michael addition reaction of these compounds with thiols in micellar systems aiming to understand the effect of hydrophobic partition on the reactivity of nitroalkenes. We studied NATxME in vitro showing it exerts non-conventional anti-inflammatory responses by inducing Nrf2-Keap1-dependent gene expression and inhibiting the secretion of NF-κB dependent pro-inflammatory cytokines. NATxME was also effective in vivo, inhibiting neutrophil recruitment in a zebrafish model of inflammation. This work lays the foundation for the rational design of a new therapeutic strategy for the prevention and treatment of metabolic and inflammation-related diseases | es |
| dc.format.extent | Extensión | 12 p. | - |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Rodríguez-Duarte, J., et al.Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses. Scientific Reports, 2018, 8: 12784. doi: 10.1038/s41598-018-31218-7 | es |
| dc.identifier.doi | DOI | 10.1038/s41598-018-31218-7 | es |
| dc.identifier.issn | ISSN | 2045-2322 | es |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/22000 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | Nature Publishing Group | es |
| dc.relation.ispartof | EN | Scientific Reports, 2018, 8, art. no. 12784 | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad De La República. (Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución (CC –BY 4.0) | es |
| dc.subject | Palabras clave | Inflammation | es |
| dc.subject | Palabras clave | Nitroalkenes | es |
| dc.subject | Palabras clave | Metabolic diseases | es |
| dc.title | Título | Electrophilic nitroalkene-tocopherol derivatives: synthesis, physicochemical characterization and evaluation of anti-inflammatory signaling responses | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 101038s41598018312187.pdf | — | 2.36 MB | Adobe PDF |