Título:
TLR7 agonist in combination with Salmonella as an effective antimelanoma immunotherapy
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Autor:
Vola, Magdalena
Monaco, Amy
Bascuas, Thais
Rimsky, Geraldine
Agorio, Caroline Isabel
Chabalgoity, José Alejandro
Moreno, María
Monaco, Amy
Bascuas, Thais
Rimsky, Geraldine
Agorio, Caroline Isabel
Chabalgoity, José Alejandro
Moreno, María
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Tipo de documento:
Artículo
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Palabras clave:
Experimental model
Imiquimod
Immunotherapy
Melanoma
Salmonella
Imiquimod
Immunotherapy
Melanoma
Salmonella
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Año de publicación:
2018
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Resumen:
Aim: We evaluated a novel approach combining the use of attenuated Salmonella immunotherapy with a Toll-like receptor agonist, imiquimod, in B16F1 melanoma-bearing mice.
Materials & methods: B16F1 melanoma-bearing mice were daily treated with topical imiquimod in combination with one intratumoral injection of attenuated Salmonella enterica serovar Typhimurium LVR01.
Results: The combined therapy resulted in retarded tumor growth and prolonged survival. Combination treatment led to an enhancement in the expression of pro-inflammatory cytokines and chemokines in the tumor microenvironment, with a Th1-skewed profile, resulting in a broad antitumor response. The induced immunity was effective in controlling the occurrence of metastasis.
Conclusion: Salmonella LVR01 immunotherapy in combination with imiquimod is a novel approach that could be considered as an effective antimelanoma therapy.
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Immunotherapy. 2018, 10(8)
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Citación:
VOLA, M., MÓNACO, A., BASCUAS, T., y otros. TLR7 agonist in combination with Salmonella as an effective antimelanoma immunotherapy. Immunotherapy [en línea] 2018, 10(8), 665-679. DOI: 10.2217/imt-2017-0188.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| I+S pdf publicado.pdf | Artículo original | 1.02 MB | Adobe PDF |