| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Chang, Fei | - |
| dc.contributor.author | Autor | Gunderstofte, Camila | - |
| dc.contributor.author | Autor | Colussi, Nicole | - |
| dc.contributor.author | Autor | Pitts, Mareena | - |
| dc.contributor.author | Autor | Salvatore, S.R. | - |
| dc.contributor.author | Autor | Thielke, Anne L. | - |
| dc.contributor.author | Autor | Turell Novo, Lucía | - |
| dc.contributor.author | Autor | Alvarez, Beatriz | - |
| dc.contributor.author | Autor | Goldbach-Mansky, Raphaela | - |
| dc.contributor.author | Autor | Villacorta, Luis | - |
| dc.contributor.author | Autor | Holm, Christian K. | - |
| dc.contributor.author | Autor | Schopfer, F.J. | - |
| dc.contributor.author | Autor | Hansen, Anne Louise | - |
| dc.contributor.filiacion | Filiación | Chang Fei | - |
| dc.contributor.filiacion | Filiación | Gunderstofte Camila | - |
| dc.contributor.filiacion | Filiación | Colussi Nicole | - |
| dc.contributor.filiacion | Filiación | Pitts Mareena | - |
| dc.contributor.filiacion | Filiación | Salvatore S.R. | - |
| dc.contributor.filiacion | Filiación | Thielke Anne L. | - |
| dc.contributor.filiacion | Filiación | Turell Novo Lucía | - |
| dc.contributor.filiacion | Filiación | Alvarez Beatriz, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. | - |
| dc.contributor.filiacion | Filiación | Goldbach-Mansky Raphaela | - |
| dc.contributor.filiacion | Filiación | Villacorta Luis | - |
| dc.contributor.filiacion | Filiación | Holm Christian K. | - |
| dc.contributor.filiacion | Filiación | Schopfer F.J. | - |
| dc.contributor.filiacion | Filiación | Hansen Anne Louise | - |
| dc.date.accessioned | Fecha ingreso | 2025-07-02T16:41:56Z | - |
| dc.date.available | Fecha disponible | 2025-07-02T16:41:56Z | - |
| dc.date.issued | Año de publicación | 2024 | - |
| dc.description | Descripción | Información suplementaria en: https://doi.org/10.1016/j.redox.2024.103202 | es |
| dc.description.abstract | Resumen | Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challenging, with no compounds in the pipeline beyond the preclinical stage. We previously identified endogenous nitrated fatty acids as novel reversible STING inhibitors. With the aim of improving the specificity and efficacy of these compounds, we developed and tested a library of nitroalkene-based compounds for in vitro and in vivo STING inhibition. The structure-activity relationship study revealed a robustly improved electrophilicity and reduced degrees of freedom of nitroalkenes by conjugation with an aromatic moiety. The lead compounds CP-36 and CP-45, featuring a β-nitrostyrene moiety, potently inhibited STING activity in vitro and relieved STING-dependent inflammation in vivo. This validates the potential for nitroalkene compounds as drug candidates for STING modulation to treat STING-driven inflammatory diseases, providing new robust leads for preclinical development. | es |
| dc.format.extent | Extensión | 14 h | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Chang, F, Gunderstofte, C, Colussi, N [y otros autores]. "Development of nitroalkene-based inhibitors to target STING-dependent inflammation". Redox Biology. [en línea] 2024, 74: 103202. 14 h. DOI: 10.1016/j.redox.2024.103202 | es |
| dc.identifier.doi | DOI | 10.1016/j.redox.2024.103202 | - |
| dc.identifier.issn | ISSN | 2213-2317 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/50451 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | Elsevier | es |
| dc.relation.ispartof | EN | Redox Biology, 2024, 74: 103202. | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución - No Comercial - Sin Derivadas (CC - By-NC-ND 4.0) | es |
| dc.subject | Palabras clave | Stimulator of Interferon Genes | es |
| dc.subject | Palabras clave | Drug discovery Nitroalkene-based compounds | es |
| dc.subject | Palabras clave | STING inhibitors | es |
| dc.subject | Palabras clave | STING-associated vasculopathy with onset in infancy | es |
| dc.subject | Palabras clave | Interferon | es |
| dc.title | Título | Development of nitroalkene-based inhibitors to target STING-dependent inflammation | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1016-j.redox.2024.103202.pdf | — | 10.32 MB | Adobe PDF |