Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/54864

Título:

Nanochitin and nanochitosan in pharmaceutical applications: innovations, applications, and future perspective

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Autor:

Vega-Baudrit, José Roberto
Lopretti, Mary Isabel
Montes de Oca-Vásquez, Gabriela
Camacho, Melissa
Batista, Diego
Corrales-Ureña, Yendry
Araya, Andrea
Bahloul, Badr
Corvis, Yohann
Castillo Henríquez, Luis

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Tipo de documento:

Artículo

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Palabras clave:

Chitin
Nanochitin
Nanochitosan
Chitosan
Biocompatibility
Drug delivery
Therapeutic needs

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Año de publicación:

2025

Contenido:

Resumen:

Nanochitin is a nanoscale form of chitin—a polysaccharide found in the exoskeletons of crustaceans, insects, and some fungal cell walls—that is newly garnering significant attention in the pharmaceutical space. Its good properties, such as biocompatibility, biodegradability, and an easily adjustable surface, render it attractive for various medical and pharmaceutical applications. Nanochitin, from drug delivery systems and wound-care formulations to vaccine adjuvants and antimicrobial strategies, has demonstrated its strong potential in meeting diverse therapeutic needs. This review covers the background of nanochitin, including methods for its extraction and refining and its principal physicochemical and biological properties. It further discusses various hydrolysis and enzymatic approaches for the structural and functional characterization of nanochitin and highlights some pharmaceutical applications where this biopolymer has been studied. The review also addresses toxicity issues, regulatory matters, and challenges in large- scale industrial production. Finally, it underscores novel avenues of investigation and future opportunities, emphasizing the urgent requirement for standardized production methods, rigorous safety assessment, and interdisciplinary partnerships to maximize nanochitin’s potential in pharmaceutical research, demonstrating the importance of chitin in drug delivery.

Descripción:

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MDPI

EN:

Pharmaceutics, 2025, 17(5): 576.

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Citación:

Vega-Baudrit, J, Lopretti, M, Montes de Oca-Vásquez, G [y otros autores]. "Nanochitin and nanochitosan in pharmaceutical applications: innovations, applications, and future perspective". Pharmaceutics. [en línea] 2025, 17(5): 576. 38 h. DOI: 10.3390/ pharmaceutics17050576

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ISSN:

1999-4923

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Licencia Creative Commons Atribución (CC - By 4.0)

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