Título:
New nitric oxide-releasing compounds as promising anti-bladder cancer drugs
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Autor:
Varela, María
López, Miriam
Ingold, Mariana
Alem, Diego
Perini, Valentina
Perelmuter, Karen
Bollati-Fogolín, Mariela
López, Gloria V.
Hernández, Paola
López, Miriam
Ingold, Mariana
Alem, Diego
Perini, Valentina
Perelmuter, Karen
Bollati-Fogolín, Mariela
López, Gloria V.
Hernández, Paola
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Tipo de documento:
Artículo
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Descriptores:
CANCER DE VEJIGA
FUROXANOS
OXIDO NITRICO
FUROXANOS
OXIDO NITRICO
Año de publicación:
2023
Contenido:
Resumen:
Bladder cancer is a worldwide problem and improved therapies are urgently needed. In the search for newer strong antitumor compounds, herein, we present the study of three nitric oxide-releasing compounds and evaluate them as possible therapies for this malignancy. Bladder cancer cell lines T24 and 253J were used to evaluate the antiproliferative, antimigratory, and genotoxic effects of compounds. Moreover, we determined the NF-κB pathway inhibition, and finally, the survivin downregulation exerted by our molecules. The results revealed that compounds 1 and 3 exerted a high antiproliferative activity against bladder cancer cells through DNA damage and survivin downregulation. In addition, compound 3 reduced bladder cancer cell migration. We found that nitric oxide donors are promising molecules for the development of a new therapeutic targeting the underlying mechanisms of tumorigenesis and progression of bladder cancer.
Descripción:
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MDPI
EN:
Biomedicines, v.11, n°1, 2023. -- 18 h.
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Citación:
Varela, M, López, M, Ingold, M, y otros. "New nitric oxide-releasing compounds as promising anti-bladder cancer drugs". Biomedicines. [en línea] 2023, vol.11, n°1, 18 h. DOI: https://doi.org/10.3390/biomedicines11010199
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| AA Varela, M. et al v.11 Biomedicines 2023.pdf | — | 5.01 MB | Adobe PDF |