Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/30969

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Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review

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Silveira, Felipe Martins
Rodrigues Mello, Andre Luiz
da Silva Fonseca, Laura
Dos Santos Ferreira, Luise
Borges Kirschnick, Laura
Domingues Martins, Manoela
Schuch, Lauren Frenzel
Almeida de Arruda, Jose Alcides
Dantas Soares, Ciro
De Oliveiras Sales, Alexandre
Bologna-Molina, Ronell
Santos-Silva, Alan Roger
Vasconcelos, Ana Carolina Uchoa

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Palabras clave:

COVID-19
Oral pathology
Molecular pathology Pandemics
SARS-CoV-2

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Año de publicación:

2022

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Resumen:

Objective: This living systematic review aims to integrate the morphological and tissue-based molecular caracterization of oral lesions occurring in individuals infected by COVID-19 (OLICs). Materials and Design: This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Web of Science, Scopus, Ovid, Embase, and LILACS were searched to identify reports on OLICs with morphological and/or tissue-based molecular data. Results: Four studies reporting five cases were included. Three patients were male, and the mean age of the individuals was 47.6 years. The most reported anatomical location was the palate (n = 4), whereas ulcers were the most frequent clinical presentation (n = 3). Histopathologically, all cases revealed cell vacuolization and exocytosis in the epithelial layer. In the mesenchymal layer, inflammatory cell infiltrate and thrombi/microvascular thrombosis were observed in three cases. Immunohistochemical reactions were performed in two cases. Both cases were negative for HHV-1, HHV-2, and CMV. One case revealed positivity for SARS-CoV-2 spike protein. No other molecular tests were found for the characterization of OLIC. Conclusions: The pathological characteristics of OLICs are still unspecific. However, with the ongoing COVID-19 pandemic and well-documented new cases, whether OLICs are due to coinfections or has a primary origin can be determined.

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Archives of Oral Biology 136 (2022) 105374

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Silveira, F, Rodrigues Mello, A, da Silva Fonseca, L, y otros . "Morphological and tissue-based molecular characterization of oral lesions in patients with COVID-19: A living systematic review"Archives of Oral Biology 136 (2022) 105374 [en línea] 2022. doi.org/10.1016/j.archoralbio.2022.105374

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Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.0)

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Publicaciones académicas y científicas 2020-
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