Título:
Comparative genome analysis of the genus Shewanella unravels the association of key genetic traits with known and potential pathogenic lineages
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Autor:
Cerbino, Gabriela N.
Traglia, Germán M.
Ayala Nuñez, Teolincacihuatl
Parmeciano Di Noto, Gisela
Ramírez, María Soledad
Centrón, Daniela
Iriarte, Andrés
Quiroga, Cecilia
Traglia, Germán M.
Ayala Nuñez, Teolincacihuatl
Parmeciano Di Noto, Gisela
Ramírez, María Soledad
Centrón, Daniela
Iriarte, Andrés
Quiroga, Cecilia
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Artículo
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Palabras clave:
Shewanella
Accessory genome
Horizontal gene transfer
Mobilome
Resistome
Virulome
Accessory genome
Horizontal gene transfer
Mobilome
Resistome
Virulome
Descriptores:
TRANSFERENCIA DE GEN HORIZONTAL
GENOMA
BACILOS GRAMNEGATIVOS ANAEROBIOS FACULTATIVOS
GENOMA
BACILOS GRAMNEGATIVOS ANAEROBIOS FACULTATIVOS
Año de publicación:
2023
Contenido:
Resumen:
Shewanella spp. are Gram-negative rods widely disseminated in aquatic niches that can also be found in human-associated environments. In recent years, reports of infections caused by these bacteria have increased significantly. Mobilome and resistome analysis of a few species showed that they are versatile; however, comprehensive comparative studies in the genus are lacking. Here, we analyzed the genetic traits of 144 genomes from Shewanella spp. isolates focusing on the mobilome, resistome, and virulome to establish their evolutionary relationship and detect unique features based on their genome content and habitat. Shewanella spp. showed a great diversity of mobile genetic elements (MGEs), most of them associated with monophyletic lineages of clinical isolates. Furthermore, 79/144 genomes encoded at least one antimicrobial resistant gene with their highest occurrence in clinical-related lineages. CRISPR-Cas systems, which confer immunity against MGEs, were found in 41 genomes being I-E and I-F the more frequent ones. Virulome analysis showed that all Shewanella spp. encoded different virulence genes (motility, quorum sensing, biofilm, adherence, etc.) that may confer adaptive advantages for survival against hosts. Our data revealed that key accessory genes are frequently found in two major clinical-related groups, which encompass the opportunistic pathogens Shewanella algae and Shewanella xiamenensis together with several other species. This work highlights the evolutionary nature of Shewanella spp. genomes, capable of acquiring different key genetic traits that contribute to their adaptation to different niches and facilitate the emergence of more resistant and virulent isolates that impact directly on human and animal health.
Descripción:
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Frontiers
EN:
Frontiers in Microbiology. 2023;14
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Citación:
Cerbino G, Traglia G, Ayala Nuñez T y otros. Comparative genome analysis of the genus Shewanella unravels the association of key genetic traits with known and potential pathogenic lineages. Frontiers in Microbiology [en línea]. 2023;14. 15 p.
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1664-302X
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Comparative genome analysis of the genus Shewanella.pdf | Comparative genome analysis of the genus Shewanella | 10.32 MB | Adobe PDF |