Título:
Composite end points and competing risks analysis
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Autor:
Dayan, Víctor
Grant, Stuart W.
Brophy, James M.
Barili, Fabio
Freemantle, Nick
Grant, Stuart W.
Brophy, James M.
Barili, Fabio
Freemantle, Nick
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Tipo de documento:
Artículo
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Palabras clave:
Competing risks
Composite outcomes
Statistics
Composite outcomes
Statistics
Descriptores:
ENSAYOS CLÍNICOS COMO ASUNTO
BIOESTADÍSTICA
MEDICIÓN DEL RIESGO
ESTADÍSTICAS DE SALUD
BIOESTADÍSTICA
MEDICIÓN DEL RIESGO
ESTADÍSTICAS DE SALUD
Año de publicación:
2024
Contenido:
Resumen:
Composite end points are common primary outcomes in clinical trials. Their main benefit of utilizing a composite outcome is increasing the number of primary outcome events, meaning fewer participants are required to deliver an adequately powered trial. By combining multiple important end points in the primary outcome rather than having to select only 1, composite end points potentially make clinically meaningful benefits easier to detect and avoid ranking outcomes hierarchically. However, there are a number of important considerations when designing and interpreting clinical trials that utilize composite end points. In this Statistical Primer, issues with composite end points such as competing events, halo effect, risk of bias, time-to-event limitations and the win ratio are discussed in the context of real world clinical trials.
Descripción:
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Editorial:
Oxford University Press
EN:
Interdisciplinary Cardiovascular and Thoracic Surgery. 2024;39(1)
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Citación:
Dayan V, Grant S, Brophy J y otros. Composite end points and competing risks analysis. Interdisciplinary Cardiovascular and Thoracic Surgery [en línea]. 2024;39(1). 6 p.
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| Composite end points and competing risks analysis.pdf | Composite end points and competing risks analysis | 2.58 MB | Adobe PDF |