Por favor, use este identificador para citar o enlazar este ítem: https://hdl.handle.net/20.500.12008/55230

Título:

Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives

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Autor:

Berois, Nora
Pittini, Álvaro
Osinaga, Eduardo

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Tipo de documento:

Artículo

Editor:

Palabras clave:

Tumor glycans
Cancer immunotherapy
Cancer glycobiology
Monoclonal antibodies
Cancer vaccines
CAR-T cells

Descriptores:

NEOPLASIAS
POLISACÁRIDOS
GLYCOBIOLOGÍA
INMUNOTERAPIA ADOPTIVA
VACUNAS CONTRA EL CÁNCER
LINFOCITOS T

Año de publicación:

2022

Contenido:

Resumen:

Aberrant glycosylation is a common feature of many cancers, and it plays crucial roles in tumor development and biology. Cancer progression can be regulated by several physiopathological processes controlled by glycosylation, such as cell–cell adhesion, cell–matrix interaction, epithelial-to-mesenchymal transition, tumor proliferation, invasion, and metastasis. Different mechanisms of aberrant glycosylation lead to the formation of tumor-associated carbohydrate antigens (TACAs), which are suitable for selective cancer targeting, as well as novel antitumor immunotherapy approaches. This review summarizes the strategies developed in cancer immunotherapy targeting TACAs, analyzing molecular and cellular mechanisms and state-of-the-art methods in clinical oncology.

Descripción:

Editorial:

MDPI

EN:

Cancers. 2022;14(3)

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Citación:

Berois N, Pittini Á y Osinaga E. Targeting Tumor Glycans for Cancer Therapy: Successes, Limitations, and Perspectives. Cancers [en línea]. 2022;14(3). 42 p.

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https://hdl.handle.net/20.500.12008/55230

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Licencia Creative Commons Atribución (CC - By 4.0)

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Targeting Tumor Glycans for Cancer Therapy.pdf Targeting Tumor Glycans for Cancer Therapy 73.23 MB Adobe PDF
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