| Metadato | Etiqueta | Valor | Idioma |
|---|---|---|---|
| dc.contributor.author | Autor | Sharkova, Maria | - |
| dc.contributor.author | Autor | Aparicio Díaz, Hector Gonzalo | - |
| dc.contributor.author | Autor | Mouzaaber, Constantin | - |
| dc.contributor.author | Autor | Zolessi, Flavio R. | - |
| dc.contributor.author | Autor | Hocking, Jennifer C. | - |
| dc.contributor.filiacion | Filiación | Sharkova Maria | - |
| dc.contributor.filiacion | Filiación | Aparicio Díaz Hector Gonzalo, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
| dc.contributor.filiacion | Filiación | Mouzaaber Constantin | - |
| dc.contributor.filiacion | Filiación | Zolessi Flavio R., Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. | - |
| dc.contributor.filiacion | Filiación | Hocking Jennifer C. | - |
| dc.date.accessioned | Fecha ingreso | 2024-04-02T15:31:16Z | - |
| dc.date.available | Fecha disponible | 2024-04-02T15:31:16Z | - |
| dc.date.issued | Año de publicación | 2024 | - |
| dc.description | Descripción | Versión aceptada (Postprint) | es |
| dc.description.abstract | Resumen | Vertebrate photoreceptors detect light through a large cilium-based outer segment, which is filled with photopigment-laden membranous discs. Surrounding the base of the outer segment are microvilli-like calyceal processes (CPs). While CP disruption has been associated with altered outer segment morphology and photoreceptor degeneration, the role of the processes remains elusive. Here, we used zebrafish as a model to characterize CPs. We quantified CP parameters and report a strong disparity in outer segment coverage between photoreceptor subtypes. CP length is stable across light and dark conditions, while heat shock inducible expression of tagged actin revealed rapid turnover of the CP actin core. Detailed imaging of the embryonic retina uncovered substantial remodeling of the developing photoreceptor apical surface, including a transition from dynamic tangential processes to vertically-oriented CPs immediately prior to outer segment formation. Remarkably, we also found a direct connection between apical extensions of the Müller glia and retinal pigment epithelium, arranged as bundles around the ultraviolet sensitive cones. In summary, our data characterize the structure, development, and surrounding environment of photoreceptor microvilli in the zebrafish retina. | es |
| dc.format.extent | Extensión | 36 h. | es |
| dc.format.mimetype | Formato | application/pdf | es |
| dc.identifier.citation | Citación | Sharkova, M, Aparicio Díaz, H, Mouzaaber, C [y otros autores]. "Photoreceptor calyceal processes accompany the developing outer segment, adopting a stable length despite a dynamic core". Journal of Cell Science. 2024. 36 h. DOI: 10.1242/jcs.261721. | es |
| dc.identifier.doi | DOI | 10.1242/jcs.261721 | - |
| dc.identifier.issn | ISSN | 1477-9137 | - |
| dc.identifier.uri | URI | https://hdl.handle.net/20.500.12008/43306 | - |
| dc.language.iso | Idioma | en | es |
| dc.publisher | Editorial | The Company of Biologists | es |
| dc.relation.ispartof | EN | Journal of Cell Science, 2024. | es |
| dc.rights | Derechos | Las obras depositadas en el Repositorio se rigen por la Ordenanza de los Derechos de la Propiedad Intelectual de la Universidad de la República.(Res. Nº 91 de C.D.C. de 8/III/1994 – D.O. 7/IV/1994) y por la Ordenanza del Repositorio Abierto de la Universidad de la República (Res. Nº 16 de C.D.C. de 07/10/2014) | es |
| dc.rights.licence | Licencia | Licencia Creative Commons Atribución (CC - By 4.0) | es |
| dc.subject | Palabras clave | Photoreceptors | es |
| dc.subject | Palabras clave | Actin | es |
| dc.subject | Palabras clave | Microvilli | es |
| dc.subject | Palabras clave | Zebrafish | es |
| dc.subject | Palabras clave | Retinal pigment epithelium | es |
| dc.subject | Palabras clave | Müller glia | es |
| dc.title | Título | Photoreceptor calyceal processes accompany the developing outer segment, adopting a stable length despite a dynamic core | es |
| dc.type | Tipo de documento | Artículo | es |
Colecciones:
| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.1242.jcs.261721.pdf | — | 1.76 MB | Adobe PDF |