Título:
Advancements in the synthesis and biological properties of carboranes and high‑boron related compounds: a comprehensive exploration with emphasis on BNCT applications
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Autor:
Couto, Marcos
Cerecetto, Hugo
Cerecetto, Hugo
Tutor:
Tipo de documento:
Artículo
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Palabras clave:
Boron-containing molecules
Carborane
Metallacarborane
Boron neutron capture therapy (BNCT)
Carborane
Metallacarborane
Boron neutron capture therapy (BNCT)
Descriptores:
Año de publicación:
2024
Contenido:
Resumen:
Since Locher proposed the concept of boron neutron capture therapy (BNCT) in 1936, it has become a great challenge in the field of medicinal chemistry. The great dare has been to obtain boron-containing compounds that selectively accumulate in the organ to be irradiated. Polyhedral boron clusters (PBC) have been considered attractive moieties for the development of BNCT-agents due to their large contribution of boron per molecule. Various issues arose in the first efforts to develop PBC during the 1940-1950s that prevented their application in BNCT clinical trials, such as a lack of selectivity and low boron tumor-accumulation. Currently, the most studied PBC in BNCT are the icosahedral dicarba-closo-dodecaboranes (C2B10H12) commonly referred to carboranes and, to a lesser extent, their mono-anionic derivatives resulting from the loss of a B-vertex, commonly known as nido-carborane, and their metal complexes, known as metallacarboranes. This review will cover the medicinal chemistry of PBC for BNCT.
Descripción:
Editorial:
Brazilian Chemical Society
EN:
Journal of the Brazilian Chemical Society, 2024, 35(10): e20240109.
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Citación:
Couto, M y Cerecetto, H. "Advancements in the synthesis and biological properties of carboranes and high‑boron related compounds: a comprehensive exploration with emphasis on BNCT applications". Journal of the Brazilian Chemical Society. [en línea] 2024, 35(10): e20240109. 35 h. DOI: 10.21577/0103-5053.20240109
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URI:
https://hdl.handle.net/20.500.12008/50279
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ISSN:
1678-4790
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Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| 10.21577-0103-5053.20240109.pdf | — | 4.37 MB | Adobe PDF |