Título:
The intracellular cation channel TMEM176B as a dual immunoregulator
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Autor:
Hill, Marcelo
Russo, Sofía
Olivera, Daniela
Malcuori, Mateo
Galliussi, Germán
Segovia, Mercedes
Russo, Sofía
Olivera, Daniela
Malcuori, Mateo
Galliussi, Germán
Segovia, Mercedes
Tutor:
Tipo de documento:
Artículo
Editor:
Palabras clave:
Immunoregulation
Antigen presentation
Inflammasomes
Tmem176b
Ion channels
Antigen presentation
Inflammasomes
Tmem176b
Ion channels
Descriptores:
PRESENTACIÓN DE ANTÍGENO
INFLAMASOMAS
CANALES IÓNICOS
INMUNIDAD
CÉLULAS DENDRÍTICAS
ANTÍGENOS
LINFOCITOS T
INFLAMASOMAS
CANALES IÓNICOS
INMUNIDAD
CÉLULAS DENDRÍTICAS
ANTÍGENOS
LINFOCITOS T
Año de publicación:
2022
Contenido:
Resumen:
Characterizing immune regulatory pathways is critical to understand physiological and pathophysiological processes as well as to identify novel immunotherapeutic targets. The cation channel TMEM176B has emerged in the last years as a potential new immunoregulatory player and pharmacological target. Here, we review how expression data, clinical associations of genetic variants and functional studies support a dual role for TMEM176B in regulating immune responses. Thus, TMEM176B can inhibit effector immune responses in some settings whereas it may also promote immunity by supporting antigen presentation in others. We also discuss a potential role for TMEM176B in regulating type 2 and 3 immunity and comment recent data on modulation of DC biology and inflammasome activation as well as CD8⁺ T cell responses. Understanding the role of TMEM176B in immunity is critical to propose rational pharmacological approaches targeting this channel.
Descripción:
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Editorial:
Frontiers Media
EN:
Frontiers in Cell and Developmental Biology. 2022;10
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Citación:
Hill M, Russo S, Olivera D y otros. The intracellular cation channel TMEM176B as a dual immunoregulator. Frontiers in Cell and Developmental Biology [en línea]. 2022;10. 8 p.
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Licencia:
Licencia Creative Commons Atribución (CC - By 4.0)
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| Ficheros | Descripción | Tamaño | Formato | ||
|---|---|---|---|---|---|
| The intracellular cation channel.pdf | The intracellular cation channel | 16.12 MB | Adobe PDF |